RefMet Compound Details

RefMet ID, RefMet name, exact mass and formula
RefMet IDRM0135644
RefMet nameLanosterol
Systematic namelanosta-8,24-dien-3beta-ol
SynonymsPubChem Synonyms
Sum CompositionST 30:2;O View other entries in RefMet with this sum composition
Exact mass426.386165 (neutral)
Calculate m/z:   
View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
FormulaC30H50OView other entries in RefMet with this formula
Molecular descriptors
Molfile34377 (Download molfile/View MW Metabolite Database details)
InChIInChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,
31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1
InChIKeyCAHGCLMLTWQZNJ-BQNIITSRSA-NView other enantiomers/diastereomers of this metabolite in RefMet
SMILESCC(=CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@@H](C(C)(C)[C@@H]1CC3)O)C
Run Tanimoto similarity search (with similarity coefficient >=0.6)
Chemical/Biochemical Classification
Super ClassSterol Lipids
Main ClassSterols
Sub ClassCholesterols
Distribution of Lanosterol in NMDR studies
SpeciesPlot Species distribution
Sample sourcePlot Sample source(tissue) distribution
StudiesNMDR Studies reporting Lanosterol
External Links
Pubchem CID246983
LIPID MAPSLMST01010017
ChEBI ID16521
KEGG IDC01724
HMDB IDHMDB0001251
Chemspider ID216175
MetaCyc IDLANOSTEROL
EPA CompToxDTXCID20209674
Spectral data for Lanosterol standards
MassBank(EU)View MS spectra
Structural annotation level
Annotation level1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Lanosterol

Rxn IDKEGG ReactionEnzyme
R03199 (S)-2,3-Epoxysqualene <=> Lanosterol(S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming)
R03689 Lanosterol + NADPH + H+ <=> 24,25-Dihydrolanosterol + NADP+lanosterol delta24-reductase
R05640 Lanosterol + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2Olanosterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)
R12323 Lanosterol + 6 Reduced ferredoxin + 6 H+ + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 6 Oxidized ferredoxin + 4 H2Olanosterol,reduced ferredoxin:oxygen oxidoreductase (14-methyl cleaving)

Table of KEGG human pathways containing Lanosterol

Pathway IDHuman Pathway# of reactions
hsa00100 Steroid biosynthesis 4
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