RefMet Compound Details

MW structure50967 (View MW Metabolite Database details)
RefMet nameHomocysteine
Systematic name2-amino-4-sulfanylbutanoic acid
SMILESC(CS)[C@@H](C(=O)O)N   Run Tanimoto similarity search (with similarity coefficient >=0.6)
Exact mass135.035401 (neutral)
Calculate m/z:   
View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
FormulaC4H9NO2SView other entries in RefMet with this formula
InChIKeyFFFHZYDWPBMWHY-VKHMYHEASA-NView other enantiomers/diastereomers of this metabolite in RefMet
Super ClassOrganic acids
Main ClassAmino acids and peptides
Sub ClassAmino acids
Pubchem CID91552
Annotation level1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Homocysteine

Rxn IDKEGG ReactionEnzyme
R00192 S-Adenosyl-L-homocysteine + H2O <=> Adenosine + L-HomocysteineS-Adenosyl-L-homocysteine hydrolase
R02821 Betaine + L-Homocysteine <=> N,N-Dimethylglycine + L-MethionineTrimethylaminoacetate:L-homosysteine S-methyltransferase
R01290 L-Serine + L-Homocysteine <=> L-Cystathionine + H2OL-serine hydro-lyase (adding homocysteine
R00946 5-Methyltetrahydrofolate + L-Homocysteine <=> Tetrahydrofolate + L-Methionine5-Methyltetrahydrofolate:L-homocysteine S-methyltransferase
R00650 S-Adenosyl-L-methionine + L-Homocysteine <=> S-Adenosyl-L-homocysteine + L-MethionineS-Adenosyl-L-methionine:L-homocysteine S-methyltransferase
R04405 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase
R10305 O-Acetyl-L-serine + L-Homocysteine <=> L-Cystathionine + AcetateO3-acetyl-L-serine:L-homocysteine S-(2-amino-2-carboxyethyl)transferase
R01286 L-Cystathionine + H2O <=> L-Homocysteine + Ammonia + PyruvateL-cystathionine L-homocysteine-lyase (deaminating

Table of KEGG human pathways containing Homocysteine

Pathway IDHuman Pathway# of reactions
hsa00270 Cysteine and methionine metabolism 6
hsa00260 Glycine, serine and threonine metabolism 2
hsa01100 Metabolic pathways 2
hsa01230 Biosynthesis of amino acids 2
hsa00670 One carbon pool by folate 1