Summary of Study ST002134

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001352. The data can be accessed directly via it's Project DOI: 10.21228/M8ZD7C This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002134
Study TitleAlignment and Analysis of a Disparately Acquired Multi-Batch Metabolomics Study of Maternal Pregnancy Samples (Part 1)
Study SummaryThis is an untargeted RPLC-MS metabolomics study of mother-infant pairs from the State of Michigan. Maternal plasma was collected in the first and third trimesters of gestation, as well as umbilical cord blood, with the aim of studying metabolic changes throughout pregnancy and influences on the infant's metabolome. The data is split into two experiment subsets, assayed with different H2O-methanol gradients and mass spectrometers 2-3 years apart, inducing major chromatographic and signal measurement shifts. Analysis steps consisted of disparate LC-MS alignment and data normalization, followed by differential timepoint comparisons and partial correlation network construction.
Institute
University of Michigan
DepartmentComputational Medicine and Bioinformatics
Last NameHabra
First NameHani
Address100 Washtenaw Ave., Palmer Commons Bldg. Ann Arbor, MI 48109-2218
Emailhhani@umich.edu
Phone734-615-9314
Submit Date2022-04-13
Raw Data AvailableYes
Analysis Type DetailLC-MS
Release Date2022-05-02
Release Version1
Hani Habra Hani Habra
https://dx.doi.org/10.21228/M8ZD7C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Project:

Project ID:PR001352
Project DOI:doi: 10.21228/M8ZD7C
Project Title:Influence of prenatal exposures to metals, BPA, and phthalates on mother and child metabolite and lipid profiles
Project Summary:The goal of the project is to examine relationships between prenatal exposures (to metals, BPA, and phthalates) and metabolite and lipid profiles using untargeted approaches in mother-infant pairs from the Michigan Mother Infant Pairs (MMIP) cohort. We are interested in differences/correlations between family samples over time, and the extent to which maternal exposures impact the lipidomes and metabolomes of both family members. Three plasma samples were analyzed from each family: two maternal samples (from first trimester and time of admission for labor and delivery) and one child sample (from cord blood). Placentas were also collected. Mothers provided detailed demographic information and clinical phenotypes were obtained, including mid-gestation fetal ultrasound.
Institute:University of Michigan
Department:Biomedical Research Core Facilities
Laboratory:Metabolomics core
Last Name:Kachman
First Name:Maureen
Address:2900 Huron Parkway, Ann Arbor, MI, 48105, USA
Email:mkachman@med.umich.edu
Phone:734-232-0842

Subject:

Subject ID:SU002219
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id SampleType BATCH LIPIDOMICS_BATCH
SA204825-- - -
SA204826M3_VP_ARMII_195Delivery maternal plasma 1 1
SA204827M3_VP_ARMII_149Delivery maternal plasma 1 1
SA204828M3_VP_ARMII_136Delivery maternal plasma 1 1
SA204829M3_VP_ARMII_193Delivery maternal plasma 1 1
SA204830M3_VP_ARMII_205Delivery maternal plasma 1 1
SA204831M3_VP_ARMII_178Delivery maternal plasma 1 1
SA204832M3_VP_ARMII_165Delivery maternal plasma 1 1
SA204833M3_VP_ARMII_163Delivery maternal plasma 1 1
SA204834M3_VP_ARMII_166Delivery maternal plasma 1 1
SA204835M3_VP_ARMII_153Delivery maternal plasma 1 1
SA204836M3_VP_ARMII_135Delivery maternal plasma 1 1
SA204837M3_VP_ARMII_120Delivery maternal plasma 1 1
SA204838M3_VP_ARMII_117Delivery maternal plasma 1 1
SA204839M3_VP_ARMII_208Delivery maternal plasma 1 1
SA204840M3_VP_ARMII_118Delivery maternal plasma 1 1
SA204841M3_VP_ARMII_228Delivery maternal plasma 1 1
SA204842M3_VP_ARMII_134Delivery maternal plasma 1 1
SA204843M3_VP_ARMII_128Delivery maternal plasma 1 1
SA204844M3_VP_ARMII_221Delivery maternal plasma 1 1
SA204845M3_VP_ARMII_164Delivery maternal plasma 2 2
SA204846M3_VP_ARMII_159Delivery maternal plasma 2 2
SA204847M3_VP_ARMII_152Delivery maternal plasma 2 2
SA204848M3_VP_ARMII_142Delivery maternal plasma 2 2
SA204849M3_VP_ARMII_121Delivery maternal plasma 2 2
SA204850M3_VP_ARMII_119Delivery maternal plasma 2 2
SA204851M3_VP_ARMII_154Delivery maternal plasma 2 2
SA204852M3_VP_ARMII_143Delivery maternal plasma 2 2
SA204853M3_VP_ARMII_210Delivery maternal plasma 2 2
SA204854M3_VP_ARMII_200Delivery maternal plasma 2 2
SA204855M3_VP_ARMII_185Delivery maternal plasma 2 2
SA204856M3_VP_ARMII_211Delivery maternal plasma 2 2
SA204857M3_VP_ARMII_218Delivery maternal plasma 2 2
SA204858M3_VP_ARMII_220Delivery maternal plasma 2 2
SA204859M3_VP_ARMII_219Delivery maternal plasma 2 2
SA204860M3_VP_ARMII_180Delivery maternal plasma 2 2
SA204861M3_VP_ARMII_207Delivery maternal plasma 2 2
SA204862M3_VP_ARMII_161Delivery maternal plasma 2 3
SA204863M3_VP_ARMII_223Delivery maternal plasma 2 3
SA204864M3_VP_ARMII_155Delivery maternal plasma 3 3
SA204865M3_VP_ARMII_133Delivery maternal plasma 3 3
SA204866M3_VP_ARMII_162Delivery maternal plasma 3 3
SA204867M3_VP_ARMII_177Delivery maternal plasma 3 3
SA204868M3_VP_ARMII_174Delivery maternal plasma 3 3
SA204869M3_VP_ARMII_173Delivery maternal plasma 3 3
SA204870M3_VP_ARMII_222Delivery maternal plasma 3 3
SA204871M3_VP_ARMII_175Delivery maternal plasma 3 3
SA204872M3_VP_ARMII_127Delivery maternal plasma 3 3
SA204873M3_VP_ARMII_150Delivery maternal plasma 3 3
SA204874M3_VP_ARMII_151Delivery maternal plasma 3 3
SA204875M3_VP_ARMII_158Delivery maternal plasma 3 3
SA204876M3_VP_ARMII_182Delivery maternal plasma 3 3
SA204877M3_VP_ARMII_199Delivery maternal plasma 3 3
SA204878M3_VP_ARMII_157Delivery maternal plasma 3 3
SA204879M3_VP_ARMII_206Delivery maternal plasma 3 3
SA204880M3_VP_ARMII_137Delivery maternal plasma 3 3
SA204881M3_VP_ARMII_179Delivery maternal plasma 3 3
SA204882M1_VP_ARMII_165First trimester maternal plasma 1 1
SA204883M1_VP_ARMII_163First trimester maternal plasma 1 1
SA204884M1_VP_ARMII_166First trimester maternal plasma 1 1
SA204885M1_VP_ARMII_193First trimester maternal plasma 1 1
SA204886M1_VP_ARMII_153First trimester maternal plasma 1 1
SA204887M1_VP_ARMII_178First trimester maternal plasma 1 1
SA204888M1_VP_ARMII_117First trimester maternal plasma 1 1
SA204889M1_VP_ARMII_195First trimester maternal plasma 1 1
SA204890M1_VP_ARMII_135First trimester maternal plasma 1 1
SA204891M1_VP_ARMII_118First trimester maternal plasma 1 1
SA204892M1_VP_ARMII_134First trimester maternal plasma 1 1
SA204893M1_VP_ARMII_136First trimester maternal plasma 1 1
SA204894M1_VP_ARMII_228First trimester maternal plasma 1 1
SA204895M1_VP_ARMII_221First trimester maternal plasma 1 1
SA204896M1_VP_ARMII_205First trimester maternal plasma 1 1
SA204897M1_VP_ARMII_208First trimester maternal plasma 1 1
SA204898M1_VP_ARMII_120First trimester maternal plasma 2 1
SA204899M1_VP_ARMII_149First trimester maternal plasma 2 1
SA204900M1_VP_ARMII_128First trimester maternal plasma 2 1
SA204901M1_VP_ARMII_142First trimester maternal plasma 2 2
SA204902M1_VP_ARMII_218First trimester maternal plasma 2 2
SA204903M1_VP_ARMII_220First trimester maternal plasma 2 2
SA204904M1_VP_ARMII_152First trimester maternal plasma 2 2
SA204905M1_VP_ARMII_219First trimester maternal plasma 2 2
SA204906M1_VP_ARMII_154First trimester maternal plasma 2 2
SA204907M1_VP_ARMII_207First trimester maternal plasma 2 2
SA204908M1_VP_ARMII_180First trimester maternal plasma 2 2
SA204909M1_VP_ARMII_185First trimester maternal plasma 2 2
SA204910M1_VP_ARMII_164First trimester maternal plasma 2 2
SA204911M1_VP_ARMII_210First trimester maternal plasma 2 2
SA204912M1_VP_ARMII_200First trimester maternal plasma 2 2
SA204913M1_VP_ARMII_159First trimester maternal plasma 2 2
SA204914M1_VP_ARMII_211First trimester maternal plasma 2 2
SA204915M1_VP_ARMII_143First trimester maternal plasma 2 2
SA204916M1_VP_ARMII_119First trimester maternal plasma 2 2
SA204917M1_VP_ARMII_121First trimester maternal plasma 2 2
SA204918M1_VP_ARMII_223First trimester maternal plasma 2 3
SA204919M1_VP_ARMII_161First trimester maternal plasma 2 3
SA204920M1_VP_ARMII_206First trimester maternal plasma 3 3
SA204921M1_VP_ARMII_179First trimester maternal plasma 3 3
SA204922M1_VP_ARMII_158First trimester maternal plasma 3 3
SA204923M1_VP_ARMII_157First trimester maternal plasma 3 3
SA204924M1_VP_ARMII_162First trimester maternal plasma 3 3
Showing page 1 of 2     Results:    1  2  Next     Showing results 1 to 100 of 199

Collection:

Collection ID:CO002212
Collection Summary:Standard blood plasma collection protocol
Sample Type:Blood (plasma)

Treatment:

Treatment ID:TR002231
Treatment Summary:This is observational study

Sample Preparation:

Sampleprep ID:SP002225
Sampleprep Summary:Standard MRC2 untargeted metabolomics and lipidomics sample preparation protocols
Sampleprep Protocol Filename:araskind_20210615_101412_PR_SP_A004_Shotgun_Lipidomics.PDF
araskind_20210611_105341_PR_SP_Untargeted_metabolomics_analysis.DOC

Combined analysis:

Analysis ID AN003489 AN003490 AN003491 AN003492
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase Reversed phase
Chromatography system Agilent 1290 Infinity II Agilent 1290 Infinity II Shimadzu Prominence UFLC Shimadzu Prominence UFLC
Column Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um)
MS Type ESI ESI ESI ESI
MS instrument type QTOF QTOF Triple TOF Triple TOF
MS instrument name Agilent 6545 QTOF Agilent 6545 QTOF ABI Sciex 5600+ TripleTOF ABI Sciex 5600+ TripleTOF
Ion Mode NEGATIVE POSITIVE NEGATIVE POSITIVE
Units Peak area Peak area Peak area, normalized Peak area, normalized

Chromatography:

Chromatography ID:CH002575
Chromatography Summary:Untargeted reverse phase LCMS, negative mode
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH002576
Chromatography Summary:Untargeted reverse phase LCMS, positive mode
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH002577
Chromatography Summary:Lipidomics reverse phase LCMS, negative mode
Instrument Name:Shimadzu Prominence UFLC
Column Name:Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH002578
Chromatography Summary:Lipidomics reverse phase LCMS, positivemode
Instrument Name:Shimadzu Prominence UFLC
Column Name:Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS003249
Analysis ID:AN003489
Instrument Name:Agilent 6545 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Acquisition method: RP Neg Untargeted_2016_460ulmin_Agilent.m, Processing in Agilent Qual/MPP followed by in-house scripts
Ion Mode:NEGATIVE
  
MS ID:MS003250
Analysis ID:AN003490
Instrument Name:Agilent 6545 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Acquisition method: RP Pos Untargeted_2016_Agilent_460ulmin_2mm.m, Processing in Agilent Qual/MPP followed by in-house scripts
Ion Mode:POSITIVE
  
MS ID:MS003251
Analysis ID:AN003491
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
MS Comments:Acquisition method LIP_15min_MSMS_Jenny_New_20min_Negative.dam, Processing in Sciex proprietary software followed by in-house scripts
Ion Mode:NEGATIVE
  
MS ID:MS003252
Analysis ID:AN003492
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
MS Comments:Acquisition method LIP_15min_MSMS_Jenny_new_20min_Positive.dam, Processing in Sciex proprietary software followed by in-house scripts
Ion Mode:POSITIVE
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