Summary of Study ST003661
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002271. The data can be accessed directly via it's Project DOI: 10.21228/M82V6D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003661 |
| Study Title | Lipidomics facilitates the discovery of diagnostic biomarkers in patients with chronic total occlusion during the perioperative period |
| Study Summary | Chronic total occlusion (CTO) is a subtype of cardiovascular disease associated with high mortality and an increased risk of ventricular arrhythmia. This study aimed to investigate lipidomic changes in CTO patients undergoing percutaneous coronary intervention (PCI) using a tandem-lipidomic strategy. We first applied a global lipidomic approach to identify the serum lipidomes of CTO-PCI patients during the perioperative period, successfully separating and identifying over 1,500 lipids. Based on these results, a Multiple Reaction Monitoring (MRM) quantification method was developed and employed for targeted lipidomic analysis. Using a high-throughput MRM tandem liquid chromatography-mass spectrometry approach, 613 lipids were successfully quantified in CTO-PCI patients and control donors. PA 18:2/11:0 emerged as a potential biomarker for distinguishing CTO patients from those suspected of having the condition. Notably, patients with different prognostic outcomes exhibited significantly distinct serum lipidomes in both pre- and post-CTO-PCI samples. This finding suggests that lipidomic data hold significant potential not only for monitoring postoperative prognosis but also for predicting surgical outcomes |
| Institute | Zhongshan Hospital Fudan University |
| Last Name | Wang |
| First Name | Zhenxin |
| Address | 136 Yi Xue Yuan Road |
| wang.zhenxin@zs-hospital.sh.cn | |
| Phone | +8618817976583 |
| Submit Date | 2024-12-04 |
| Num Groups | 4 |
| Total Subjects | 63 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | wiff |
| Analysis Type Detail | LC-MS |
| Release Date | 2025-01-20 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR003803 |
| Treatment Summary: | Furthermore, lipid profiling during the preoperative and postoperative phases of CTO-PCI patients may assist in assessing preoperative risk and predicting postoperative outcomes. The evaluation of circulating lipid alterations in CTO-PCI patients throughout the perioperative period using both shotgun and MRM lipidomics showed that systematic lipid changes have significant potential for predicting and monitoring the prognostic effects of CTO-PCI. |
