Summary of Study ST002841

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001779. The data can be accessed directly via it's Project DOI: 10.21228/M8RM7K This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002841
Study TitleCollaborative role of YqgC and superoxide dismutase (MnSOD) in manganese intoxication: Replicate Experiment 2
Study TypeTargeted MS Analysis
Study SummaryIn this study, we are validating the mutual impact of yqgC and superoxide dismutase (MnSOD) deletion (YS strain) and resultant hypersensitivity to Manganese (Mn). Our genetic and physiological studies show that Mn intoxication is a result of distinct enzymatic vulnerabilities via alleviated expression of Mg-dependent, chorismate-utilizing enzymes of the menaquinone, siderophore, and tryptophan (MST) family (due to mismetalation).
Cornell University
LaboratoryRhee Lab
Last NameSoni
First NameVijay
AddressWeill Cornell Medical College, 413 E 69th St
Submit Date2023-08-28
Num Groups10
Total Subjects60
Study CommentsNA
Raw Data AvailableYes
Raw Data File Type(s)mzML
Chear StudyNA
Analysis Type DetailLC-MS
Release Date2023-09-21
Release Version1
Vijay Soni Vijay Soni application/zip

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Treatment ID:TR002960
Treatment Summary:All strains were treated without (control group) or with (treated group) 0.15 mM of MnCl2 for 60 min at 37 ˚C.
Treatment Protocol ID:NA
Treatment Protocol Filename:NA
Treatment Protocol Comments:NA
Treatment Compound:MnCl2 salt
Treatment Route:Direct in bacterial culture
Treatment Dose:0.15 mM
Treatment Dosevolume:NA
Treatment Doseduration:NA
Treatment Vehicle:Water
Cell Storage:-80
Cell Growth Container:Flask
Cell Growth Config:200 rpm
Cell Growth Rate:40-60 min
Cell Inoc Proc:NA
Cell Media:LB Media
Cell Envir Cond:NA
Cell Harvesting:acetonitrile:methanol:water (40:40:20)
Cell Pct Confluence:0.4 OD600
Cell Media Lastchanged:NA