Summary of Study ST001848

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001165. The data can be accessed directly via it's Project DOI: 10.21228/M8411V This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001848
Study TitleUntargeted mass spectrometry reveals impact of high fat diet on peripheral amino acid regulation in a mouse model of Alzheimer’s Disease
Study Typeuntargeted metabolomics analysis
Study SummaryAPPSwe/PS1ΔE9 (APP/PSEN1) transgenic mice (to represent familial or early-onset AD) and wild-type litter mater controls were fed either a high-fat diet (HFD, 60% kcal from lard), low-fat diet (LFD, 10% kcal from lard) from 2 months of age, or reversal diet (REV, high-fat followed by low-fat from 9.5 months).
Vanderbilt University
LaboratoryCenter for Innovative Technology
Last NameCodreanu
First NameSimona
Address3009, Liberty Hills Drive
Submit Date2021-06-03
Num Groups6
Total Subjects36
Num Males18
Num Females18
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Simona Codreanu Simona Codreanu application/zip

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Treatment ID:TR001937
Treatment Summary:Briefly, at 2-months of age, standard lab chow (Purina 5001, 4% kcal/fat) was replaced with either HFD in which 60% kcal are derived from lard, 20% from carbohydrate and 20% from protein, or low-fat diet (LFD) control in which 10% kcal are derived from lard and additional calories are derived from corn starch, with 70% from carbohydrates and 20% from protein.33 For the reversal group (REV), a subset of mice on the HFD was provided with a LFD, at 9.5 months of age, for the study duration.33 All other mice were maintained on their original experimental diets until the end of the study, which was an additional 10 weeks.