Summary of Study ST001503

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001015. The data can be accessed directly via it's Project DOI: 10.21228/M8H40X This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001503
Study TitleMetabolomics reveals the protective effect of isosteviol sodium against multiple organ injury in septic mice - Kidney
Study SummarySepsis is a severe inflammatory disorder that can lead to multiple organ injury. Isosteviol sodium (STV-Na) is a terpenoid derived from stevioside that exerts anti-inflammatory, antioxidant and anticancer activities. However, the influence of STV-Na on sepsis remains unknown. Here, we assessed the potential effects of STV-Na on sepsis and multiple organ injury induced by lipopolysaccharide (LPS). We found that STV-Na increased the survival rate of mice treat with LPS, significantly improved the functions of the heart, lung, liver, and kidney, and reduced the production of inflammatory cytokines. Moreover, Multiorgan metabolomics analysis demonstrated that glutathione metabolism, purine metabolism, glycerophospholipid metabolism and pantothenate and CoA biosynthesis, were significantly altered by STV-Na. This study provides novel insights into the metabolite changes of multiple organ injury in septic mice, which may help characterize the underlying mechanism and provide an improved understanding of the therapeutic effects of STV-Na on sepsis.
Guangdong University of Technology
Last NameWang
First NameShanping
AddressNo. 100, Waihuan Xilu, Guangzhou Higher Education Mega Center, Panyu District,
Submit Date2020-09-29
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2021-03-01
Release Version1
Shanping Wang Shanping Wang application/zip

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Treatment ID:TR001592
Treatment Summary:After being acclimatized for 1 week, the mice were separated, at random, into four groups: 1) saline + saline; 2) saline + LPS; 3) STV-Na+ LPS; and 4) dexamethasone (Dex) + LPS. Mice were intraperitoneally administered saline (0.1 mL/10 g) or STV-Na (5, 10, 20 mg/kg) and Dex (10 mg/kg) two times per day every 12 h for 3 consecutive days, and one hour after the first intraperitoneal injection on day 3, saline (0.1 mL/g body weight) or LPS from E. coli (0111: B4, 20 mg/kg) was intraperitoneally administered.
Treatment Protocol Filename:shanpingwang_Treatment_Protocol.docx