Summary of Study ST000635

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000457. The data can be accessed directly via it's Project DOI: 10.21228/M8060Z This work is supported by NIH grant, U2C- DK119886.

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Study ID	ST000635
Study Title	Amino Acid Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from DASH2 Clinical Trial (part VIII)
Study Summary	The objective of the study is to identify changes of urinary metabolite profiles associated with different responses to blood pressure to salt. Subjects are derived from The Dietary approaches to stop hypertension (DASH) diet, Sodium Intake and Blood Pressure Trial (Sacks FM et al PMID: 11136953,N Engl J Med. 2001).We choose two groups subjects who meet the following conditions(the two groups are separately named A and B). We chose subjects on the Control diet .These subjects meet the blood pressure criteria described below:Group A subjects conditions: 1) On Control diet. 2) Normotensive subjects: systolic blood pressure from the low sodium visit is less than 140 and the diastolic blood pressure from low sodium visit is less than 90; 3) For group A: Either the systolic blood pressure from the high sodium visit was greater than 10 mmHg higher than the systolic blood pressure from the low sodium visit, or the diastolic blood pressure from the high sodium visit was greater than 10 mmHg higher than the diastolic blood pressure from the low sodium visit; 3) For group B: The systolic blood pressure from the high sodium visit is within 5 mmHg (i.e. +/- 5) from the systolic blood pressure from the low sodium visit, and the diastolic blood pressure from the high sodium visit is within 5 mmHg from the diastolic blood pressure from the low sodium visit. Use gas chromatography/mass spectrometry (GC/MS) analysis, and liquid chromatography/mass spectrometry (LC/MS)analysis to find the differences of metabolic profiles between the high sodium level and the low sodium level, and compare the metabolic profiles of A with the metabolic profiles of B at the low and high sodium level.
Institute	Mayo Clinic
Last Name	Liang
First Name	Mingyu
Address	Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226
Email	mliang@mcw.edu
Phone	414-955-8539
Submit Date	2017-06-23
Analysis Type Detail	LC-MS
Release Date	2019-07-17
Release Version	1

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Treatment:

Treatment ID:	TR000672
Treatment Summary:	We will analyze urine specimens collected during the Dietary Approaches to Stop Hypertension – Sodium Study (DASH-Sodium or DASH2) clinical trial. More than 400 participants in the study were divided into two groups. One followed a common Western diet, while the other group followed the “healthier” DASH diet. Then each group had three 30 day periods, in random orders, that corresponded to high, intermediate, or low sodium intakes while eating their designated diet. The participants had all of their meals prepared and provided for them during the entire study. It was found that reducing sodium intake significantly reduced blood pressure especially when on the common Western diet. We have obtained urine samples and phenotypic data for a subset of the participants of the DASH2 trial form the NHLBI biospecimen and data repository BioLINCC. We selected two sub-groups of participants on the Western diet. Group A (n=31) exhibited large (>12 mmHg) differences in systolic or diastolic pressure between low- and high-sodium intakes (“salt-sensitive” group). Group B (n=29) showed similar blood pressure (differences <5 mmHg for both systolic and diastolic pressures) between low- and high-sodium intakes (“saltinsensitive” group).

Treatment ID:

TR000672

Treatment Summary:

We will analyze urine specimens collected during the Dietary Approaches to Stop Hypertension – Sodium Study (DASH-Sodium or DASH2) clinical trial. More than 400 participants in the study were divided into two groups. One followed a common Western diet, while the other group followed the “healthier” DASH diet. Then each group had three 30 day periods, in random orders, that corresponded to high, intermediate, or low sodium intakes while eating their designated diet. The participants had all of their meals prepared and provided for them during the entire study. It was found that reducing sodium intake significantly reduced blood pressure especially when on the common Western diet. We have obtained urine samples and phenotypic data for a subset of the participants of the DASH2 trial form the NHLBI biospecimen and data repository BioLINCC. We selected two sub-groups of participants on the Western diet. Group A (n=31) exhibited large (>12 mmHg) differences in systolic or diastolic pressure between low- and high-sodium intakes (“salt-sensitive” group). Group B (n=29) showed similar blood pressure (differences <5 mmHg for both systolic and diastolic pressures) between low- and high-sodium intakes (“saltinsensitive” group).