Summary of Study ST000465
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000357. The data can be accessed directly via it's Project DOI: 10.21228/M8WW32 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000465 |
Study Title | Uniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response |
Study Type | Metabolomic effect of Englerin A on renal cell carcinoma |
Study Summary | This targeted metabolomic analysis was performed on renal cell carcinoma A498 cells with or without anti-cancer drug Englerin treatment for 24 and 48 h. |
Institute | University of California, San Diego |
Department | Department of Pediatrics |
Last Name | Batova |
First Name | Ayse |
Address | La Jolla, CA 92093 |
abatova@ucsd.edu | |
Phone | 619-543-1962 |
Submit Date | 2016-09-09 |
Num Groups | Two groups for 24 h treatment (control and Eglerin treatment) and two groups for 48 h treatment. Each has 4 replicates |
Total Subjects | 16 |
Analysis Type Detail | LC-MS |
Release Date | 2016-12-22 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR000500 |
Treatment Summary: | A498 cells were plated in 100mm dishes at 0.5 x 106 and 1 x 106 cells/dish in complete RPMI for control and treated cells, respectively. The following day, cells were refed with complete RPMI containing 0.1% DMSO or 100 nM englerin A in DMSO with each condition being conducted in quadruplicate. Cells were incubated with vehicle or englerin A for 24 or 48 h and then they were snap frozen with liquid nitrogen. |
Treatment: | Anticaner drug |
Treatment Compound: | Englerin A |
Treatment Route: | Direct incubation |
Treatment Dose: | 100 nM |
Treatment Doseduration: | 24hr and 48hr |