Summary of Study ST004035
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002527. The data can be accessed directly via it's Project DOI: 10.21228/M80R9W This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST004035 |
| Study Title | Serum Metabolites at Defined Stages of Liver Disease |
| Study Summary | The goal of this study was to reveal serum metabolome differences at defined stages of liver disease from fatty liver to hepatocellular carcinoma. This study investigates serum metabolomic alterations in a mouse model of non-alcoholic steatohepatitis (NASH) and HCC) using the STAM (Streptozotocin and High-Fat Diet) model. Male mice were administered streptozotocin (STZ) shortly after birth and subsequently fed a high-fat diet to induce liver disease progression resembling human NASH and HCC. Blood samples were collected at a defined disease stage , and serum was isolated for untargeted metabolomic profiling. Using LC-MS, we profiled the serum metabolites to identify disease-associated metabolic signatures. The study parameters include treatment condition (control vs. STAM), sample collection time (e.g., ZT8), and serum metabolite intensity values. Analysis revealed significant changes in pathways related to lipid metabolism, bile acid biosynthesis, amino acid metabolism, and energy homeostasis in the STAM group compared to controls. These metabolic alterations may reflect the systemic metabolic disturbances associated with NASH progression and HCC risk, providing potential biomarkers and therapeutic targets. |
| Institute | University of Texas Health Science Center at Houston |
| Department | IMM |
| Laboratory | Mahan Lab |
| Last Name | Fekry |
| First Name | Baharan |
| Address | The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), 1825 Pressler St, Houston TX 77030, USA. |
| Baharan.Fekry@uth.tmc.edu | |
| Phone | 18434693199 |
| Submit Date | 2025-07-02 |
| Analysis Type Detail | LC-MS |
| Release Date | 2025-07-15 |
| Release Version | 1 |
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Subject:
| Subject ID: | SU004181 |
| Subject Type: | Mammal |
| Subject Species: | Mus musculus |
| Taxonomy ID: | 10090 |
