Summary of Study ST003423
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002116. The data can be accessed directly via it's Project DOI: 10.21228/M83N8D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003423 |
| Study Title | Impact of ACLY and ACSS2 on the development of MASLD on longterm Western diet |
| Study Summary | To further assess the impact of ACLY and ACSS2 on the development of MASLD on Western diet, we also carried out longer term experiments, in which mice remained on diet for 22 weeks. Exacerbated steatosis was apparent in the liver ACLY KO and DKO mice, both histologically and by TAG quantification. Further lipid analysis by LC-MS revealed elevated DAGs and cholesterol esters (CEs) in ACLY-deficient and DKO livers, along with reduced abundance of phosphatidylcholines (PCs). Together the data indicate that ACLY deficiency results in perturbed lipid metabolism in the liver, with accumulation of TAGs, DAGs, and CEs. |
| Institute | Salk Institute for Biological Studies |
| Last Name | KUNA |
| First Name | RAMYA |
| Address | 10010 N Torrey Pines Rd, La Jolla, California, 92037, USA |
| rkuna@salk.edu | |
| Phone | 8584534100 |
| Submit Date | 2024-08-13 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-08-26 |
| Release Version | 1 |
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Sample Preparation:
| Sampleprep ID: | SP003557 |
| Sampleprep Summary: | Samples were extracted with 400 ul of methanol (-20 C), 100 ul of water (ice-cold), 400 saline (ice-cold), and 1000 ul of chloroform (-20 C). |
| Processing Storage Conditions: | Room temperature |
| Extract Storage: | 4℃ |
