Summary of Study ST001949

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001236. The data can be accessed directly via it's Project DOI: 10.21228/M8Z10X This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001949
Study TitlePlasma Metabolome Normalization in Rheumatoid Arthritis following initiation of Methotrexate and the Identification of Metabolic Biomarkers of Efficacy
Study TypeClinical
Study SummaryMethotrexate (MTX) efficacy in the treatment of rheumatoid arthritis (RA) is variable and unpredictable, resulting in a need to identify biomarkers to guide drug therapy. This study evaluates changes in the plasma metabolome associated with response to MTX in RA with the goal of understanding the metabolic basis for MTX efficacy towards the identification of potential metabolic biomarkers of MTX response.
University of Kansas
DepartmentPharmacy Practice
Last NameMedcalf
First NameMatthew
Address2106 Olathe Boulevard
Submit Date2021-10-20
Num Groups3
Total Subjects40
Num Males9
Num Females31
Raw Data AvailableYes
Analysis Type DetailGC-MS
Release Date2022-11-07
Release Version1
Matthew Medcalf Matthew Medcalf application/zip

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Sample Preparation:

Sampleprep ID:SP002033
Sampleprep Summary:Plasma samples were sent to the West Coast Metabolomics Center and were processed according to laboratory Standard Operating Procedures for samples preparations of blood plasma or serum samples for lipidomic, biogenic amine, and primary metabolomic analysis using a biphasic MeOH/MTBE/Water extraction procedure. The upper organic phase was used for lipidomics analysis and the aqueous phase was used for analysis of primary metabolism and biogenic amines.
Sampleprep Protocol Filename:Biogenic_Amines.Data Processing
Lipidomics.Data Processing