Summary of Study ST001069
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000716. The data can be accessed directly via it's Project DOI: 10.21228/M8496H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001069 |
| Study Title | Evaluation of Seryl-leucine core 1 O-glycosylated peptide (SLC1G) in TB patient urine |
| Study Summary | Previous work detected an uncharacterized urine metabolite with a molecular mass of 874.3547 Da that showed promise as a biomarker for successful TB treatment. Using mass spectrometry combined with enzymatic digestions, the metabolite was structurally characterized as a seryl-leucine core 1 O-glycosylated peptide (SLC1G) of human origin. Examination of SLC1G in urine revealed a significant abundance increase in individuals with active TB versus their household contacts and healthy controls. Moreover, differential decreases in SLC1G levels were observed by week-one in TB patients during successful treatment versus those that failed treatment. The SLC1G levels also associated with clinical parameters used to measure bacterial burden (GeneXpert) and inflammation (PET-CT). These results demonstrate the importance of metabolite identification and provide strong evidence for applying SLC1G as a biomarker of TB treatment response. |
| Institute | Colorado State University |
| Last Name | Fitzgerald |
| First Name | Bryna |
| Address | 3185 Rampart Rd |
| blfitz@colostate.edu | |
| Phone | 9704918905 |
| Submit Date | 2018-10-07 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2018-12-11 |
| Release Version | 1 |
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Sample Preparation:
| Sampleprep ID: | SP001120 |
| Sampleprep Summary: | Urine was thawed on ice and centrifuged to remove particulates prior to analysis. |
