Summary of Study ST003636
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002243. The data can be accessed directly via it's Project DOI: 10.21228/M8PR8Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003636 |
| Study Title | Individual glycemic responses to carbohydrates vary and reflect underlying metabolic physiology (metabolomics) |
| Study Summary | We measured PPGRs using continuous glucose monitoring (CGM) in 55 well-phenotyped participants challenged with seven different carbohydrates administered in replicate under standardized conditions. Plasma sample were collected at baseline visit for metabolomics. The ClinicalTrials.gov registration identifier is NCT03919877. |
| Institute | Stanford University |
| Last Name | Michael |
| First Name | Snyder |
| Address | 300 Pasteur Drive, M-344A Stanford, California 94305 |
| mpsnyder@stanford.edu | |
| Phone | (650) 723-4668 |
| Submit Date | 2024-11-17 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2025-01-14 |
| Release Version | 1 |
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Project:
| Project ID: | PR002243 |
| Project DOI: | doi: 10.21228/M8PR8Q |
| Project Title: | Individual glycemic responses to carbohydrates vary and reflect underlying metabolic physiology |
| Project Summary: | Elevated postprandial glycemic responses (PPGRs) are associated with type 2 diabetes and cardiovascular disease. PPGRs to the same foods have been shown to vary between individuals, but the systematic characterization of the underlying physiologic and molecular basis is lacking. We measured PPGRs using continuous glucose monitoring (CGM) in 55 well-phenotyped participants challenged with seven different carbohydrates administered in replicate under standardized conditions. We also measured the effects of preloading a rice meal with fiber, protein, or fat (“mitigators”). To examine the physiologic and molecular basis for inter-individual PPGR differences, we performed gold-standard metabolic tests and multi-omics profiling. We discovered: 1. Postprandial glycemic responses (PPGRs) to different standardized carbohydrate meals vary between individuals. 2. Individuals’ PPGRs are associated with their metabolic phenotypes, including insulin resistance. 3. Individual’s PPGRs can be reduced in magnitude and delayed by premeal mitigators which is associated with their metabolic phenotypes. 4. Individuals can be stratified by their PPGRs to different carbohydrate meals, and PPGR subtypes have distinct metabolic profiles and multi-omics patterns. 5. Individuals’ metabolic phenotype can be inferred from both food-specific PPGRs and baseline omics. |
| Institute: | Stanford University |
| Department: | Genetics |
| Laboratory: | Michael P. Snyder |
| Last Name: | Snyder |
| First Name: | Michael |
| Address: | 300 Pasteur Drive, M-344A Stanford, California 94305 |
| Email: | mpsnyder@stanford.edu |
| Phone: | (650) 723-4668 |
| Funding Source: | NIH |
