Summary of Study ST002841

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001779. The data can be accessed directly via it's Project DOI: 10.21228/M8RM7K This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002841
Study TitleCollaborative role of YqgC and superoxide dismutase (MnSOD) in manganese intoxication: Replicate Experiment 2
Study TypeTargeted MS Analysis
Study SummaryIn this study, we are validating the mutual impact of yqgC and superoxide dismutase (MnSOD) deletion (YS strain) and resultant hypersensitivity to Manganese (Mn). Our genetic and physiological studies show that Mn intoxication is a result of distinct enzymatic vulnerabilities via alleviated expression of Mg-dependent, chorismate-utilizing enzymes of the menaquinone, siderophore, and tryptophan (MST) family (due to mismetalation).
Cornell University
LaboratoryRhee Lab
Last NameSoni
First NameVijay
AddressWeill Cornell Medical College, 413 E 69th St
Submit Date2023-08-28
Num Groups10
Total Subjects60
Study CommentsNA
Raw Data AvailableYes
Raw Data File Type(s)mzML
Chear StudyNA
Analysis Type DetailLC-MS
Release Date2023-09-21
Release Version1
Vijay Soni Vijay Soni application/zip

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Project ID:PR001779
Project DOI:doi: 10.21228/M8RM7K
Project Title:Collaborative role of YqgC and superoxide dismutase (MnSOD) in manganese intoxication
Project Type:LC-MS targettged analysis
Project Summary:Bacterial metal ion homeostasis is strongly regulated by various metalloregulators. This project is focused on the role of yqgC-soda operon of B. subtilis in Manganese (Mn) ion metal homeostasis and the dependencies of these genes to maintain bacterial survival in the excess of Mn.
Institute:Weill Cornell Medicine
Laboratory:Rhee Lab
Last Name:Soni
First Name:Vijay
Address:413 E 69TH STREET, Belfer Research Building, New York, New York, 10021, USA
Funding Source:R35GM122461, NIAID:R25 AI140472
Project Comments:NA
Contributors:Ankita J. Sachla, Vijay Soni, Yuanchan Luo, Kyu Y. Rhee, John D. Helmann