Summary of Study ST002346

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001506. The data can be accessed directly via it's Project DOI: 10.21228/M81D8C This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST002346
Study TitleLipidomics study of the cells defective in peroxisome division
Study SummaryProliferation of peroxisomes is accompanied by the growth and division of pre-existing peroxisomes. Pex11β induces the elongation of peroxisome membrane and then dynamin-like GTPase, DLP1, elicits the peroxisomal division. Nucleoside diphosphate kinase 3 (NME3) generates GTP for the DLP1 activity. Deficiencies of either of the factors induce abnormal morphology of peroxisomes. In this study, we assessed the phospholipid compositions in cells lacking each of the different division factors. In the fibroblasts from the patients deficient in DLP1, NME3, or Pex11β, docosahexaenoic acid (DHA, C22:6)-containing phospholipids were found to be decreased. Conversely, the levels of several fatty acids such as arachidonic acid (AA, C20:4) and oleic acid (C18:1) were elevated. Mouse embryonic fibroblasts from Drp1- and Pex11β-knockout mice also showed a decrease in the levels of phospholipids containing DHA and AA.
Institute
Kyushu university
Last NameAbe
First NameYuichi
Address3-1-1 Maidashi, Fukuoka 812-8582, Japan.
Emaily-abe@bio.sojo-u.ac.jp
Phone+81926426341
Submit Date2022-10-26
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2022-11-28
Release Version1
Yuichi Abe Yuichi Abe
https://dx.doi.org/10.21228/M81D8C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Project:

Project ID:PR001506
Project DOI:doi: 10.21228/M81D8C
Project Title:Lipidomics study of peroxisomal dysmorphogenesis
Project Summary:Lipidomic study of the cells defective in peroxisomal dysmorphogenesis.
Institute:Kyushu university
Last Name:Abe
First Name:Yuichi
Address:3-1-1 Maidashi, Fukuoka 812-8582, Japan.
Email:y-abe@bio.sojo-u.ac.jp
Phone:+81-92-642-6341
  logo