Summary of Study ST002313
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001483. The data can be accessed directly via it's Project DOI: 10.21228/M81M72 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002313 |
| Study Title | Dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, increases oxidative stress, alters metabolism and causes gut dybiosis in APCmin mice |
| Study Summary | Colorectal cancer (CRC) is the second most prevelant malignancy in Europe and diet is an important modifiable risk factor. Processed meat consumption, including meats with preservative salts such as sodium nitrite, have been implicated in CRC pathogenesis. This study investigated how the CRC pathology and metabolic status of adenomatous polyposis coli (APC) multiple intestinal neoplasia (min) mice was perturbed following 8 weeks of pork meat consumption.Dietary inclusions (15%) of either nitrite-free pork, nitrite-free sausage or nitrite-containing sausage (frankfurter) were compared against a parallel control group (100% chow). Comprehensive studies investigated: gastrointestinal tract histology (tumours, aberant crypt foci (ACF) and mucin deplin foci (MDF), lipid peroxidation (urine and serum), faecal microbiota and serum metabolomics (599 metabolites). |
| Institute | Institute for Global Food Security |
| Last Name | Pan |
| First Name | Xiaobei |
| Address | 19 Chlorine Gardens, Belfast, Antrim, BT9 5DL, United Kingdom |
| x.pan@qub.ac.uk | |
| Phone | 02890975984 |
| Submit Date | 2022-09-20 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Waters) |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-11-03 |
| Release Version | 1 |
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Project:
| Project ID: | PR001483 |
| Project DOI: | doi: 10.21228/M81M72 |
| Project Title: | Dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, increases oxidative stress, alters metabolism and causes gut dybiosis in APCmin mice |
| Project Summary: | This study investigated how the colorectal cancer pathology and metabolic status of adenomatous polyposis coli (APC) multiple intestinal neoplasia (min) mice was perturbed following 8 weeks of pork meat consumption. |
| Institute: | Institute for Global Food Security |
| Last Name: | Pan |
| First Name: | Xiaobei |
| Address: | 19 Chlorine Gardens, Belfast, Antrim, BT9 5DL, United Kingdom |
| Email: | x.pan@qub.ac.uk |
| Phone: | 02890975984 |
