Summary of Study ST001104

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000716. The data can be accessed directly via it's Project DOI: 10.21228/M8496H This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001104
Study TitleSeryl-leucine core 1 O-glycosylated peptide (SLC1G) identification
Study SummaryAn untargeted metabolomics approach was utilized to determine urinary metabolites that could serve as small molecule biomarkers for treatment response to standard tuberculosis treatment. However, the majority of metabolites that most accurately distinguished patient samples at time of diagnosis from those at one month after the start of therapy lacked structural identification. The detection of unknown metabolite structures is a well-known limitation of untargeted metabolomics, and underscores a need for continued elucidation of novel metabolite structures. In this study, we sought to define the structure of a urine metabolite with an experimentally determined mass of 202.1326 Da, classified as molecular feature (MF) 874.3547. Using mass spectrometry combined with enzymatic digestions, the metabolite was structurally characterized as a seryl-leucine core 1 O-glycosylated peptide (SLC1G) of human origin.
Colorado State University
Last NameFitzgerald
First NameBryna
Address3185 Rampart Rd
Submit Date2018-09-26
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2019-01-22
Release Version1
Bryna Fitzgerald Bryna Fitzgerald application/zip

Select appropriate tab below to view additional metadata details:


Project ID:PR000716
Project DOI:doi: 10.21228/M8496H
Project Title:Evaluation of TB Treatment Response Biomarkers
Project Type:Directed MS analysis
Project Summary:Directed MS analysis of promising treatment response biomarkers in TB patient urine.
Institute:Colorado State University
Department:Department of Microbiology, Immunology, and Pathology
Last Name:Fitzgerald
First Name:Bryna
Address:3185 Rampart Rd, Fort Collins, CO, 80521, USA
Funding Source:NIH U01 AI-115619