Summary of Study ST001069

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000716. The data can be accessed directly via it's Project DOI: 10.21228/M8496H This work is supported by NIH grant, U2C- DK119886.


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Study IDST001069
Study TitleEvaluation of Seryl-leucine core 1 O-glycosylated peptide (SLC1G) in TB patient urine
Study SummaryPrevious work detected an uncharacterized urine metabolite with a molecular mass of 874.3547 Da that showed promise as a biomarker for successful TB treatment. Using mass spectrometry combined with enzymatic digestions, the metabolite was structurally characterized as a seryl-leucine core 1 O-glycosylated peptide (SLC1G) of human origin. Examination of SLC1G in urine revealed a significant abundance increase in individuals with active TB versus their household contacts and healthy controls. Moreover, differential decreases in SLC1G levels were observed by week-one in TB patients during successful treatment versus those that failed treatment. The SLC1G levels also associated with clinical parameters used to measure bacterial burden (GeneXpert) and inflammation (PET-CT). These results demonstrate the importance of metabolite identification and provide strong evidence for applying SLC1G as a biomarker of TB treatment response.
Colorado State University
Last NameFitzgerald
First NameBryna
Address3185 Rampart Rd
Submit Date2018-10-07
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2018-12-11
Release Version1
Bryna Fitzgerald Bryna Fitzgerald application/zip

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Project ID:PR000716
Project DOI:doi: 10.21228/M8496H
Project Title:Evaluation of TB Treatment Response Biomarkers
Project Type:Directed MS analysis
Project Summary:Directed MS analysis of promising treatment response biomarkers in TB patient urine.
Institute:Colorado State University
Department:Department of Microbiology, Immunology, and Pathology
Last Name:Fitzgerald
First Name:Bryna
Address:3185 Rampart Rd, Fort Collins, CO, 80521, USA
Funding Source:NIH U01 AI-115619