Summary of Study ST002822

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001764. The data can be accessed directly via it's Project DOI: 10.21228/M8PT58 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002822
Study TitleEffect of ERR Agonist in Mouse Heart Post Pressure Overload
Study SummaryThe present heart dataset comprises a total of 855 biochemicals, 787 compounds of known identity (named biochemicals) and 68 compounds of unknown structural identity (unnamed biochemicals). The muscle dataset comprises a total of 711 biochemicals, 663 compounds of known identity (named biochemicals) and 48 compounds of unknown structural identity (unnamed biochemicals). Following normalization to mass of sample extracted for heart tissue (equal mass was extracted for muscle tissue samples, so no additional normalization was performed on muscle samples prior to statistical analysis), log transformation and imputation of missing values, if any, with the minimum observed value for each compound, 2-way ANOVA or Welch’s two-sample t-test analyses were used to identify biochemicals that differed significantly between experimental groups. A summary of the numbers of biochemicals that achieved statistical significance (p≤0.05), as well as those approaching significance (0.05<p<0.10), is shown below.
Institute
Baylor College of Medicine
Last NameXu
First NameWeiyi
AddressOne Baylor Plaza, Houston, TX, 77030-3498, USA
Emailweiyi.xu@bcm.edu
Phone8322755836
Submit Date2023-08-09
Analysis Type DetailOther
Release Date2024-08-09
Release Version1
Weiyi Xu Weiyi Xu
https://dx.doi.org/10.21228/M8PT58
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN004599 AN004600 AN004601 AN004602
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase HILIC
Chromatography system Waters Acquity Waters Acquity Waters Acquity Waters Acquity
Column Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um) Waters ACQUITY UPLC BEH Amide (100 x 2.1mm,1.7um) Waters ACQUITY UPLC BEH Amide (100 x 2.1mm,1.7um) Waters Acquity BEH Amide (150 x 2.1mm, 1.7um)
MS Type ESI ESI ESI ESI
MS instrument type Orbitrap Orbitrap Orbitrap Orbitrap
MS instrument name Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap
Ion Mode POSITIVE POSITIVE NEGATIVE NEGATIVE
Units log transformed data log transformed data log transformed data log transformed data

MS:

MS ID:MS004345
Analysis ID:AN004599
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Metabolon (LC/MS Pos early)
Ion Mode:POSITIVE
Analysis Protocol File:SLU_Heart_Metabolomics_method.pdf
  
MS ID:MS004346
Analysis ID:AN004600
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Metabolon (LC/MS Pos late)
Ion Mode:POSITIVE
Analysis Protocol File:SLU_Heart_Metabolomics_method.pdf
  
MS ID:MS004347
Analysis ID:AN004601
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Metabolon (LC/MS Neg)
Ion Mode:NEGATIVE
Analysis Protocol File:SLU_Heart_Metabolomics_method.pdf
  
MS ID:MS004348
Analysis ID:AN004602
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Metabolon (LC/MS Polar)
Ion Mode:NEGATIVE
Analysis Protocol File:SLU_Heart_Metabolomics_method.pdf
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