Summary of Study ST003520

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002165. The data can be accessed directly via it's Project DOI: 10.21228/M8S247 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST003520
Study TitleIdentification of Plasma Metabolomic Biomarkers of Juvenile Idiopathic Arthritis
Study TypeClinical
Study SummaryThis study utilizes plasma metabolomic profiling to identify biomarkers associated with juvenile idiopathic arthritis (JIA) by analyzing samples from treatment-naïve JIA patients and non-JIA controls. Significant metabolic alterations were detected, with sphingosine metabolites and fatty acid ethanolamides showing notable increases in JIA patients, while specific compounds such as sarcosine were decreased. The research highlights 11 highly discriminatory metabolites, including sphinganine-1-phosphate, demonstrating potential for improved JIA diagnosis and treatment through targeted metabolic profiling.
Institute
University of Kansas
DepartmentCenter for Computational Biology
LaboratoryFunk
Last NameKumar
First NameAmar
AddressMultidisciplinary Research Bldg. 2030 Becker Drive Lawrence, KS 66047
Emailamarkumar@ku.edu
Phone18723016225
Submit Date2024-09-09
Num Groups2
Total Subjects210
Num Males82
Num Females128
Study CommentsAlthough the raw dataset initially included 210 subjects, only 207 were included in the final analysis due to consent-related exclusions. These three subjects were removed to ensure compliance with ethical standards.
Analysis Type DetailLC-MS
Release Date2024-11-01
Release Version1
Amar Kumar Amar Kumar
https://dx.doi.org/10.21228/M8S247
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Group
SA386516UKAN-00680EDTA plasma Crohn's Disease
SA386517UKAN-00636EDTA plasma Crohn's Disease
SA386518UKAN-00637EDTA plasma Crohn's Disease
SA386519UKAN-00642EDTA plasma Crohn's Disease
SA386520UKAN-00643EDTA plasma Crohn's Disease
SA386521UKAN-00645EDTA plasma Crohn's Disease
SA386522UKAN-00670EDTA plasma Crohn's Disease
SA386523UKAN-00671EDTA plasma Crohn's Disease
SA386524UKAN-00674EDTA plasma Crohn's Disease
SA386525UKAN-00675EDTA plasma Crohn's Disease
SA386526UKAN-00677EDTA plasma Crohn's Disease
SA386527UKAN-00683EDTA plasma Crohn's Disease
SA386528UKAN-00633EDTA plasma Crohn's Disease
SA386529UKAN-00684EDTA plasma Crohn's Disease
SA386530UKAN-00686EDTA plasma Crohn's Disease
SA386531UKAN-00710EDTA plasma Crohn's Disease
SA386532UKAN-00714EDTA plasma Crohn's Disease
SA386533UKAN-00715EDTA plasma Crohn's Disease
SA386534UKAN-00716EDTA plasma Crohn's Disease
SA386535UKAN-00721EDTA plasma Crohn's Disease
SA386536UKAN-00723EDTA plasma Crohn's Disease
SA386537UKAN-00724EDTA plasma Crohn's Disease
SA386538UKAN-00725EDTA plasma Crohn's Disease
SA386539UKAN-00635EDTA plasma Crohn's Disease
SA386540UKAN-00712EDTA plasma Crohn's Disease
SA386541UKAN-00631EDTA plasma Crohn's Disease
SA386542UKAN-00632EDTA plasma Healthy_Control
SA386543UKAN-00827EDTA plasma Healthy_Control
SA386544UKAN-00708EDTA plasma Healthy_Control
SA386545UKAN-00707EDTA plasma Healthy_Control
SA386546UKAN-00822EDTA plasma Healthy_Control
SA386547UKAN-00823EDTA plasma Healthy_Control
SA386548UKAN-00824EDTA plasma Healthy_Control
SA386549UKAN-00825EDTA plasma Healthy_Control
SA386550UKAN-00826EDTA plasma Healthy_Control
SA386551UKAN-00829EDTA plasma Healthy_Control
SA386552UKAN-00828EDTA plasma Healthy_Control
SA386553UKAN-00711EDTA plasma Healthy_Control
SA386554UKAN-00830EDTA plasma Healthy_Control
SA386555UKAN-00831EDTA plasma Healthy_Control
SA386556UKAN-00832EDTA plasma Healthy_Control
SA386557UKAN-00833EDTA plasma Healthy_Control
SA386558UKAN-00685EDTA plasma Healthy_Control
SA386559UKAN-00682EDTA plasma Healthy_Control
SA386560UKAN-00681EDTA plasma Healthy_Control
SA386561UKAN-00709EDTA plasma Healthy_Control
SA386562UKAN-00717EDTA plasma Healthy_Control
SA386563UKAN-00713EDTA plasma Healthy_Control
SA386564UKAN-00801EDTA plasma Healthy_Control
SA386565UKAN-00793EDTA plasma Healthy_Control
SA386566UKAN-00794EDTA plasma Healthy_Control
SA386567UKAN-00795EDTA plasma Healthy_Control
SA386568UKAN-00796EDTA plasma Healthy_Control
SA386569UKAN-00797EDTA plasma Healthy_Control
SA386570UKAN-00798EDTA plasma Healthy_Control
SA386571UKAN-00799EDTA plasma Healthy_Control
SA386572UKAN-00800EDTA plasma Healthy_Control
SA386573UKAN-00802EDTA plasma Healthy_Control
SA386574UKAN-00678EDTA plasma Healthy_Control
SA386575UKAN-00803EDTA plasma Healthy_Control
SA386576UKAN-00804EDTA plasma Healthy_Control
SA386577UKAN-00726EDTA plasma Healthy_Control
SA386578UKAN-00634EDTA plasma Healthy_Control
SA386579UKAN-00722EDTA plasma Healthy_Control
SA386580UKAN-00720EDTA plasma Healthy_Control
SA386581UKAN-00719EDTA plasma Healthy_Control
SA386582UKAN-00718EDTA plasma Healthy_Control
SA386583UKAN-00679EDTA plasma Healthy_Control
SA386584UKAN-00834EDTA plasma Healthy_Control
SA386585UKAN-00853EDTA plasma Healthy_Control
SA386586UKAN-00864EDTA plasma Healthy_Control
SA386587UKAN-00854EDTA plasma Healthy_Control
SA386588UKAN-00676EDTA plasma Healthy_Control
SA386589UKAN-00852EDTA plasma Healthy_Control
SA386590UKAN-00856EDTA plasma Healthy_Control
SA386591UKAN-00857EDTA plasma Healthy_Control
SA386592UKAN-00858EDTA plasma Healthy_Control
SA386593UKAN-00859EDTA plasma Healthy_Control
SA386594UKAN-00860EDTA plasma Healthy_Control
SA386595UKAN-00861EDTA plasma Healthy_Control
SA386596UKAN-00862EDTA plasma Healthy_Control
SA386597UKAN-00855EDTA plasma Healthy_Control
SA386598UKAN-00646EDTA plasma Healthy_Control
SA386599UKAN-00863EDTA plasma Healthy_Control
SA386600UKAN-00667EDTA plasma Healthy_Control
SA386601UKAN-00668EDTA plasma Healthy_Control
SA386602UKAN-00630EDTA plasma Healthy_Control
SA386603UKAN-00629EDTA plasma Healthy_Control
SA386604UKAN-00638EDTA plasma Healthy_Control
SA386605UKAN-00673EDTA plasma Healthy_Control
SA386606UKAN-00639EDTA plasma Healthy_Control
SA386607UKAN-00640EDTA plasma Healthy_Control
SA386608UKAN-00672EDTA plasma Healthy_Control
SA386609UKAN-00641EDTA plasma Healthy_Control
SA386610UKAN-00628EDTA plasma Healthy_Control
SA386611UKAN-00627EDTA plasma Healthy_Control
SA386612UKAN-00644EDTA plasma Healthy_Control
SA386613UKAN-00669EDTA plasma Healthy_Control
SA386614UKAN-00808EDTA plasma JIA
SA386615UKAN-00809EDTA plasma JIA
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