Summary of Study ST002826

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001768. The data can be accessed directly via it's Project DOI: 10.21228/M85T5M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002826
Study TitleCold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
Study SummaryCold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge on NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with coldstimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlates negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT are related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and probably regulated in a coordinated fashion by several tissues.
Institute
University of Turku
Last NameVirtanen
First NameKirsi
AddressTurku PET Centre, Turku University Hospital, Turku, Finland
Emailkirsi.virtanen@utu.fi
Phone+358-40-7626564
Submit Date2023-08-10
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2023-09-11
Release Version1
Kirsi Virtanen Kirsi Virtanen
https://dx.doi.org/10.21228/M85T5M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA30575063cold
SA30575167cold
SA30575262cold
SA30575369cold
SA30575460cold
SA30575555cold
SA30575670cold
SA30575757cold
SA30575858cold
SA30575942cold
SA30576061cold
SA30576184cold
SA30576294cold
SA30576393cold
SA30576495cold
SA30576596cold
SA30576699cold
SA30576798cold
SA30576891cold
SA30576989cold
SA30577076cold
SA30577175cold
SA30577280cold
SA30577381cold
SA30577486cold
SA30577541cold
SA30577673cold
SA30577751cold
SA30577820cold
SA30577919cold
SA30578018cold
SA30578116cold
SA30578221cold
SA30578322cold
SA30578427cold
SA30578540cold
SA30578623cold
SA30578715cold
SA30578814cold
SA3057897cold
SA3057906cold
SA3057913cold
SA3057921cold
SA3057938cold
SA3057949cold
SA30579513cold
SA30579612cold
SA30579711cold
SA30579828cold
SA30579924cold
SA30580038cold
SA30580131cold
SA30580233cold
SA30580334cold
SA30580436cold
SA30580537cold
SA30580630cold
SA30580732cold
SA30580829cold
SA30580939cold
SA305734QC3QC
SA305735QC6QC
SA305736QC1QC
SA305737QC9QC
SA305738QC4QC
SA305739QC8QC
SA305740QC7QC
SA305741QC10QC
SA305742QC5QC
SA305743QC2QC
SA305744QC autoMSMS 40V_1QC
SA305745QC autoMSMS 40V_2QC
SA305746QC autoMSMS 20V_1QC
SA305747QC autoMSMS 10V_1QC
SA305748QC autoMSMS 20V_2QC
SA305749QC autoMSMS 10V_2QC
SA30581043warm
SA30581150warm
SA30581253warm
SA30581392warm
SA3058144warm
SA30581552warm
SA30581649warm
SA30581746warm
SA305818102warm
SA30581954warm
SA305820100warm
SA305821101warm
SA30582245warm
SA30582397warm
SA30582417warm
SA30582571warm
SA30582672warm
SA30582725warm
SA30582826warm
SA30582968warm
SA30583066warm
SA30583164warm
SA30583277warm
SA30583378warm
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