Summary of Study ST002214

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001414. The data can be accessed directly via it's Project DOI: 10.21228/M8Z42Q This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002214
Study TitleThe effects of PKM2 modulation and hypoxia on the metabolic landscape of Alzheimer patient-derived induced neurons
Study SummaryWe have obtained fibroblast cultures from old adult human non-demented control donors and Alzheimer patients (AD). The fibroblasts were reprogrammed into directly induced neurons (iNs) to serve as an adult-like and age-equivalent model for aging and neurodegeneration. Their response to PKM2 modulation (shikonin 10 ┬ÁM or PKM2 overexpression) and hypoxia (CoDo treatment) were assessed.
University of Colorado Denver
Last NameHaines
First NameJulie
Address12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA
Submit Date2022-06-24
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2022-07-25
Release Version1
Julie Haines Julie Haines application/zip

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Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Condition Treatment
SA2118688020-CAlzheimer patient DMSO
SA2118693131-CAlzheimer patient DMSO
SA2118703053-CAlzheimer patient DMSO
SA2118712800-CAlzheimer patient DMSO
SA2118722800-SAlzheimer patient Shikonin
SA2118738020-SAlzheimer patient Shikonin
SA2118743053-SAlzheimer patient Shikonin
SA2118753131-SAlzheimer patient Shikonin
SA2118768011-DFOnon-demented control CoDo Treatment
SA2118772785-DFOnon-demented control CoDo Treatment
SA2118782785-Cnon-demented control GFP-overexpression
SA2118792608-Cnon-demented control GFP-overexpression
SA2118808011-Cnon-demented control GFP-overexpression
SA2118812608-OEnon-demented control PKM2-overexpression
SA2118822785-OEnon-demented control PKM2-overexpression
SA2118838011-OEnon-demented control PKM2-overexpression
Showing results 1 to 16 of 16