Summary of Study ST001806

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001137. The data can be accessed directly via it's Project DOI: 10.21228/M8R102 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001806
Study TitleEffect of external low-dose rate radiation on mouse biofluid metabolomic signatures (part V)
Study SummaryAn important component of ionizing radiation (IR) exposure after a radiological incident may include low-dose rate (LDR) exposures either externally or internally, such as from 137Cs deposition. LDR exposures can have different effects compared to acute high-dose rate exposures from a health and biodosimetry perspective. In this study, a novel irradiation system, VAriable Dose-rate External 137Cs irradiatoR (VADER), was used to expose male and female mice to a variable LDR over a 30-day time span to cumulative doses of 1 (only in males), 2, 2.8, 4.1, 8.8 (only in males), or 9.7 Gy to simulate fall-out type exposures. Urine and serum from mice exposed to an acute dose (~0.8 Gy/min) of x-rays were collected in parallel. Radiation markers were identified by global mass spectrometry based metabolomics and the machine learning algorithm Random Forests.
Institute
Georgetown University
Last NamePannkuk
First NameEvan
Address3970 Reservoir Rd, NW New Research Building E504
Emailelp44@georgetown.edu
Phone2026875650
Submit Date2021-05-18
Raw Data AvailableYes
Raw Data File Type(s)raw(Waters)
Analysis Type DetailLC-MS
Release Date2021-12-15
Release Version1
Evan Pannkuk Evan Pannkuk
https://dx.doi.org/10.21228/M8R102
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Factor Factor
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SA16762833VControl D1
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SA167644152VControl D20
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SA167651188VControl D3
SA167652190VControl D3
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SA16765494AControl D3
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SA167659160VControl D30
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SA167662156VControl D30
SA167663158VControl D30
SA167664144VControl D5
SA167665142VControl D5
SA16766699AControl D5
SA167667141VControl D5
SA167668145VControl D5
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SA167673143VControl D5
SA16767463AHDR D1
SA16767564AHDR D1
SA16767662AHDR D1
SA16767765AHDR D1
SA16767861AHDR D1
SA16767969AHDR D2
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SA16768473AHDR D3
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SA16768671AHDR D3
SA16768774AHDR D3
SA16768875AHDR D3
SA16768976AHDR D5
SA16769079AHDR D5
SA16769180AHDR D5
SA16769278AHDR D5
SA16769377AHDR D5
SA1676941VLDR D1
SA1676954VLDR D1
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SA1676985VLDR D1
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SA167701173VLDR D2
SA167702171VLDR D2
SA167703174VLDR D2
SA167704123VLDR D20
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SA167706124VLDR D20
SA167707121VLDR D20
SA167708125VLDR D20
SA167709183VLDR D3
SA167710184VLDR D3
SA167711185VLDR D3
SA167712181VLDR D3
SA167713182VLDR D3
SA167714127VLDR D30
SA167715130VLDR D30
SA167716128VLDR D30
SA167717126VLDR D30
SA167718129VLDR D30
SA167719115VLDR D5
SA167720112VLDR D5
SA167721111VLDR D5
SA167722114VLDR D5
SA167723113VLDR D5
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