Summary of Study ST000976

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000666. The data can be accessed directly via it's Project DOI: 10.21228/M8KQ3J This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000976
Study TitleGC6-74 matabolomic of TB (Part 3: Plasma_RPMI)
Study TypeMetabolomic analysis of TB vs heathy including time to TB.
Study SummaryWithin the GC6-74 cohorts, 4,462 HIV-negative healthy household contacts of 1,098 index TB cases were recruited from 2006 to 2012 at four African sites included in this study i.e. SUN (Stellenbosch University, South Africa), MRC (Medical Research Council Unit, The Gambia), AHRI (Armauer Hansen Research Institute, Ethiopia) and MAK (Makerere University, Uganda). The study had an exclusion period of 3 months, such that participants, who were diagnosed with active TB within 3 months of enrolment, were excluded from analysis to prevent inclusion of participants who had incipient or asymptomatic clinical TB disease at enrolment. Additional exclusion criteria were positive HIV rapid test, current or previous anti-retroviral treatment, history of TB, pregnancy, participation in drug and/or vaccine clinical trials and chronic disease diagnosis or immunosuppressive therapy within the past 6 months, and living in the study area for less than 3 months. A total of 97 individuals who developed active TB within the two year follow-up period were included in this study and matched at a ratio of 1:4 with participants who remained healthy during the 2-year follow-up period (controls); matching, by site, age class, sex, and wherever possible year of recruitment. Initial samples collected upon enrolment were termed baseline (BL) samples. Further samples were taken 6 and 18 months post-exposure, provided that the participant had remained TB free at the time of sample collection. Metabolic profiling was carried out for each study site, using either serum or plasma samples. For a small number of samples, an insufficient amount of plasma was available, so the sample was diluted using RPMI buffer.
Institute
Max Planck Institute for Infection Biology
DepartmentImmunology
Last NameKaufmann
First NameStefan
AddressCharitéplatz 1,10117 Berlin, Berlin, Deutschland
Emailkaufmann@mpiib-berlin.mpg.de
Phone+49 30 28460-500
Submit Date2018-05-15
Analysis Type DetailLC-MS
Release Date2018-11-05
Release Version1
Stefan Kaufmann Stefan Kaufmann
https://dx.doi.org/10.21228/M8KQ3J
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id GROUP TIMEPOINT REGION GENDER
SA059364MPIIB.7138case BL MAK F
SA059365MPIIB.2949case BL MAK F
SA059366MPIIB.7424case BL MAK M
SA059367MPIIB.4132case BL MAK M
SA059368MPIIB.3660case BL MAK M
SA059369MPIIB.2072case BL MAK M
SA059370MPIIB.3365case BL MAK M
SA059371MPIIB.4138case M06 MAK F
SA059372MPIIB.0898case M06 MAK M
SA059373MPIIB.9763case M06 MAK M
SA059374MPIIB.7717control BL MAK F
SA059375MPIIB.2304control BL MAK F
SA059376MPIIB.2872control BL MAK F
SA059377MPIIB.4755control BL MAK F
SA059378MPIIB.3319control BL MAK F
SA059379MPIIB.3768control BL MAK F
SA059380MPIIB.2902control BL MAK M
SA059381MPIIB.2981control BL MAK M
SA059382MPIIB.3772control BL MAK M
SA059383MPIIB.7816control BL MAK M
SA059384MPIIB.9322control BL MAK M
SA059385MPIIB.9798control BL MAK M
SA059386MPIIB.8308control BL MAK M
SA059387MPIIB.6606control BL MAK M
SA059388MPIIB.5431control BL MAK M
SA059389MPIIB.6114control BL MAK M
SA059390MPIIB.5074control BL MAK M
SA059391MPIIB.8510control BL MAK M
SA059392MPIIB.0560control BL MAK M
SA059393MPIIB.7468control BL MAK M
SA059394MPIIB.4380control BL MAK M
SA059395MPIIB.6037control BL MAK M
SA059396MPIIB.5969control BL MAK M
SA059397MPIIB.8814control BL MAK M
SA059398MPIIB.7374control BL MAK M
SA059399MPIIB.4312control M06 MAK F
SA059400MPIIB.0523control M06 MAK F
SA059401MPIIB.4981control M06 MAK F
SA059402MPIIB.9818control M06 MAK F
SA059403MPIIB.4243control M06 MAK M
SA059404MPIIB.7049control M06 MAK M
SA059405MPIIB.8512control M06 MAK M
SA059406MPIIB.0240control M06 MAK M
SA059407MPIIB.3787control M06 MAK M
SA059408MPIIB.6068control M06 MAK M
Showing results 1 to 45 of 45
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