Summary of Study ST000638

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000457. The data can be accessed directly via it's Project DOI: 10.21228/M8060Z This work is supported by NIH grant, U2C- DK119886.


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Study IDST000638
Study TitleAmino Acid Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine and Kidney Tissue (part XI)
Study SummaryWe propose to analyze kidney tissue extract and urine samples from SS and SS.Fh1+ transgenic rats in addition to the analysis of urine samples from the DASH2 trial. The analysis of the rat samples will be highly valuable for several reasons. First, it will to take the findings in human subjects back to animal models and prepare us for further mechanistic studies. We hypothesize at least some of the effects of dietary salt intake on metabolite profiles in human will be recapitulated or altered in the SS rat. If this is confirmed, we will have a highly informative animal model ready for mechanistic studies in which we can investigate the functional contribution of specific metabolites to hypertension and the mechanisms involved. Second, the rat study will allow us to take advantage of a new and unique transgenic SS.Fh1+ model that we recently developed that overexpresses fumarase (Fh1) on the genetic background of the SS rat. Fumarase is a TCA cycle enzyme previously implicated in salt-induced hypertension in SS rats.
Mayo Clinic
Last NameLiang
First NameMingyu
AddressMedical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226
Submit Date2017-06-23
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Mingyu Liang Mingyu Liang application/zip

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Subject type: Rat; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id local_sample_id sample ID group
SA035975ms6104-17YCR1 kidney cortex Transgenic Het
SA035976ms6104-23YCR1 kidney cortex Transgenic Het
SA035977ms6104-21YCR1 kidney cortex Transgenic Het
SA035978ms6104-24YCR1 kidney cortex Transgenic Het
SA035979ms6104-18YCR1 kidney cortex Transgenic Negative
SA035980ms6104-22YCR1 kidney cortex Transgenic Negative
SA035981ms6104-19YCR1 kidney cortex Transgenic Negative
SA035982ms6104-20YCR1 kidney cortex Transgenic Negative
SA035983ms6104-16YCR1 outer medulla kidney Transgenic Het
SA035984ms6104-15YCR1 outer medulla kidney Transgenic Het
SA035985ms6104-13YCR1 outer medulla kidney Transgenic Het
SA035986ms6104-9YCR1 outer medulla kidney Transgenic Het
SA035987ms6104-10YCR1 outer medulla kidney Transgenic Negative
SA035988ms6104-11YCR1 outer medulla kidney Transgenic Negative
SA035989ms6104-12YCR1 outer medulla kidney Transgenic Negative
SA035990ms6104-14YCR1 outer medulla kidney Transgenic Negative
SA035991ms6104-1YCR1 urine Transgenic Het
SA035992ms6104-2YCR2 urine Transgenic Negative
SA035993ms6104-3YCR3 urine Transgenic Negative
SA035994ms6104-4YCR4 urine Transgenic Negative
SA035995ms6104-5YCR5 urine Transgenic Het
SA035996ms6104-6YCR6 urine Transgenic Negative
SA035997ms6104-7YCR7 urine Transgenic Het
SA035998ms6104-8YCR8 urine Transgenic Het
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