Summary of Study ST000584

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000427. The data can be accessed directly via it's Project DOI: 10.21228/M8VK5D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000584
Study TitleFasting wildtype, tfeb -/- knockout, and lmna -/- knockout metabolite profiling of adult zebrafish
Study SummaryInhibition of mechanistic target of rapamycin (mTOR) activity exerts cardioprotective functions. We propose to assess the metabolite profile in zebrafish cardiomyopathy models to test the cardioprotective role of mTOR-TFEB-autophagy and mTOR-lmna- autophagy signaling in heart, liver, muscle, brain, and kidney tissue. In addition mTOR signaling among zebrafish 2 hour post feeding, 24 hour post feeding, and 48 hour post feeding will be profiled. These studes will be used as a baseline and for protocol development before we assess changes in DOX-induced cardiomyopathy.
Institute
Mayo Clinic
Last NameXu
First NameXiaolei
Address200 First Street SW, Rochester, MN 55905
EmailXu.Xiaolei@mayo.edu
Phone507-284-0685
Submit Date2017-03-10
Analysis Type DetailLC-MS
Release Date2019-05-15
Release Version1
Xiaolei Xu Xiaolei Xu
https://dx.doi.org/10.21228/M8VK5D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Zebrafish; Subject species: Danio rerio (Factor headings shown in green)

mb_sample_id local_sample_id sex tissue timepoint genotype
SA030858nC18-20nov15-020-r001female heart tfeb-/- tfeb-/-
SA030859nC18-20nov15-018-r002female heart tfeb-/- tfeb-/-
SA030860nC18-20nov15-020-r002female heart tfeb-/- tfeb-/-
SA030861nC18-20nov15-018-r001female heart tfeb-/- tfeb-/-
SA030862nC18-20nov15-022-r001female heart tfeb-/- tfeb-/-
SA030863nC18-20nov15-025-r002female heart tfeb-/- tfeb-/-
SA030864nC18-20nov15-025-r001female heart tfeb-/- tfeb-/-
SA030865pC18-18nov15-025-r002female heart tfeb-/- tfeb-/-
SA030866nhilic-19nov15-025-r002female heart tfeb-/- tfeb-/-
SA030867nhilic-19nov15-025-r001female heart tfeb-/- tfeb-/-
SA030868nhilic-19nov15-020-r002female heart tfeb-/- tfeb-/-
SA030869nhilic-19nov15-020-r001female heart tfeb-/- tfeb-/-
SA030870nhilic-19nov15-018-r002female heart tfeb-/- tfeb-/-
SA030871nhilic-19nov15-022-r001female heart tfeb-/- tfeb-/-
SA030872nhilic-19nov15-022-r002female heart tfeb-/- tfeb-/-
SA030873nC18-20nov15-005-r002female heart tfeb-/- tfeb-/-
SA030874nC18-20nov15-005-r001female heart tfeb-/- tfeb-/-
SA030875philic-18nov15-005-r001female heart tfeb-/- tfeb-/-
SA030876philic-18nov15-005-r002female heart tfeb-/- tfeb-/-
SA030877pC18-18nov15-018-r002female heart tfeb-/- tfeb-/-
SA030878pC18-18nov15-018-r001female heart tfeb-/- tfeb-/-
SA030879pC18-18nov15-005-r002female heart tfeb-/- tfeb-/-
SA030880pC18-18nov15-020-r001female heart tfeb-/- tfeb-/-
SA030881pC18-18nov15-020-r002female heart tfeb-/- tfeb-/-
SA030882pC18-18nov15-025-r001female heart tfeb-/- tfeb-/-
SA030883pC18-18nov15-022-r002female heart tfeb-/- tfeb-/-
SA030884pC18-18nov15-022-r001female heart tfeb-/- tfeb-/-
SA030885pC18-18nov15-005-r001female heart tfeb-/- tfeb-/-
SA030886philic-18nov15-018-r001female heart tfeb-/- tfeb-/-
SA030887philic-18nov15-022-r002female heart tfeb-/- tfeb-/-
SA030888philic-18nov15-025-r001female heart tfeb-/- tfeb-/-
SA030889philic-18nov15-025-r002female heart tfeb-/- tfeb-/-
SA030890philic-18nov15-022-r001female heart tfeb-/- tfeb-/-
SA030891philic-18nov15-020-r002female heart tfeb-/- tfeb-/-
SA030892philic-18nov15-018-r002female heart tfeb-/- tfeb-/-
SA030893philic-18nov15-020-r001female heart tfeb-/- tfeb-/-
SA030894nhilic-19nov15-018-r001female heart tfeb-/- tfeb-/-
SA030895nC18-20nov15-022-r002female heart tfeb-/- tfeb-/-
SA030896nhilic-19nov15-005-r001female heart tfeb-/- tfeb-/-
SA030897nhilic-19nov15-005-r002female heart tfeb-/- tfeb-/-
SA030898nC18-26nov15-023-r002female kidney tfeb-/- tfeb-/-
SA030899nC18-26nov15-023-r001female kidney tfeb-/- tfeb-/-
SA030900philic-24nov15-005-r002female kidney tfeb-/- tfeb-/-
SA030901pC18-24nov15-023-r002_1female kidney tfeb-/- tfeb-/-
SA030902philic-24nov15-015-r001female kidney tfeb-/- tfeb-/-
SA030903philic-24nov15-017-r002female kidney tfeb-/- tfeb-/-
SA030904philic-24nov15-017-r001female kidney tfeb-/- tfeb-/-
SA030905philic-24nov15-015-r002female kidney tfeb-/- tfeb-/-
SA030906nhilic-25nov15-012-r001female kidney tfeb-/- tfeb-/-
SA030907nhilic-25nov15-012-r002female kidney tfeb-/- tfeb-/-
SA030908nhilic-25nov15-017-r002female kidney tfeb-/- tfeb-/-
SA030909nhilic-25nov15-017-r001female kidney tfeb-/- tfeb-/-
SA030910nhilic-25nov15-015-r002female kidney tfeb-/- tfeb-/-
SA030911nhilic-25nov15-023-r001female kidney tfeb-/- tfeb-/-
SA030912philic-24nov15-005-r001female kidney tfeb-/- tfeb-/-
SA030913philic-24nov15-023-r002female kidney tfeb-/- tfeb-/-
SA030914philic-24nov15-023-r001female kidney tfeb-/- tfeb-/-
SA030915nhilic-25nov15-023-r002female kidney tfeb-/- tfeb-/-
SA030916nhilic-25nov15-005-r002female kidney tfeb-/- tfeb-/-
SA030917pC18-24nov15-017-r002_1female kidney tfeb-/- tfeb-/-
SA030918nC18-26nov15-005-r001female kidney tfeb-/- tfeb-/-
SA030919nC18-26nov15-015-r001female kidney tfeb-/- tfeb-/-
SA030920nC18-26nov15-015-r002female kidney tfeb-/- tfeb-/-
SA030921nC18-26nov15-017-r001female kidney tfeb-/- tfeb-/-
SA030922nC18-26nov15-005-r002female kidney tfeb-/- tfeb-/-
SA030923pC18-24nov15-005-r002_1female kidney tfeb-/- tfeb-/-
SA030924nC18-26nov15-012-r001female kidney tfeb-/- tfeb-/-
SA030925nC18-26nov15-012-r002female kidney tfeb-/- tfeb-/-
SA030926pC18-24nov15-005-r001_1female kidney tfeb-/- tfeb-/-
SA030927pC18-24nov15-012-r001_1female kidney tfeb-/- tfeb-/-
SA030928nC18-26nov15-017-r002female kidney tfeb-/- tfeb-/-
SA030929philic-24nov15-012-r002female kidney tfeb-/- tfeb-/-
SA030930nhilic-25nov15-005-r001female kidney tfeb-/- tfeb-/-
SA030931nhilic-25nov15-015-r001female kidney tfeb-/- tfeb-/-
SA030932pC18-24nov15-017-r001_1female kidney tfeb-/- tfeb-/-
SA030933pC18-24nov15-015-r002_1female kidney tfeb-/- tfeb-/-
SA030934philic-24nov15-012-r001female kidney tfeb-/- tfeb-/-
SA030935pC18-24nov15-012-r002_1female kidney tfeb-/- tfeb-/-
SA030936pC18-24nov15-015-r001_1female kidney tfeb-/- tfeb-/-
SA030937pC18-24nov15-023-r001_1female kidney tfeb-/- tfeb-/-
SA030938pC18-11nov15-019-r001female muscle tfeb-/- tfeb-/-
SA030939pC18-11nov15-022-r002female muscle tfeb-/- tfeb-/-
SA030940nhilic-12nov15-015-r001female muscle tfeb-/- tfeb-/-
SA030941nhilic-12nov15-015-r002female muscle tfeb-/- tfeb-/-
SA030942pC18-11nov15-022-r001female muscle tfeb-/- tfeb-/-
SA030943pC18-11nov15-019-r002female muscle tfeb-/- tfeb-/-
SA030944pC18-11nov15-016-r001female muscle tfeb-/- tfeb-/-
SA030945pC18-11nov15-016-r002female muscle tfeb-/- tfeb-/-
SA030946pC18-11nov15-015-r002female muscle tfeb-/- tfeb-/-
SA030947pC18-11nov15-003-r002female muscle tfeb-/- tfeb-/-
SA030948philic-11nov15-016-r001female muscle tfeb-/- tfeb-/-
SA030949philic-11nov15-016-r002female muscle tfeb-/- tfeb-/-
SA030950philic-11nov15-015-r002female muscle tfeb-/- tfeb-/-
SA030951philic-11nov15-015-r001female muscle tfeb-/- tfeb-/-
SA030952philic-11nov15-003-r001female muscle tfeb-/- tfeb-/-
SA030953philic-11nov15-003-r002female muscle tfeb-/- tfeb-/-
SA030954philic-11nov15-019-r001female muscle tfeb-/- tfeb-/-
SA030955philic-11nov15-019-r002female muscle tfeb-/- tfeb-/-
SA030956nhilic-12nov15-003-r001female muscle tfeb-/- tfeb-/-
SA030957nhilic-12nov15-003-r002female muscle tfeb-/- tfeb-/-
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