Summary of Study ST003452
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002126. The data can be accessed directly via it's Project DOI: 10.21228/M8T52T This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST003452 |
| Study Title | Integrated Proteomic and Lipidomic Analysis |
| Study Summary | GNB1 and SCARB2 genes were knocked down in human subcutaneous adipocytes using RNA interference. Both proteomic and lipidomic analyses were performed using mass spectrometry. The proteomic results revealed significant changes in the expression levels of key proteins involved in lipid metabolism and adipogenesis. The lipidomic analysis identified significant changes in lipid species, including phosphatidylcholines, ceramides, and cholesterol esters. This integrated analysis provides insights into the molecular pathways and lipid metabolism regulated by GNB1 and SCARB2 in adipocyte function. |
| Institute | Hamamatsu University School of Medicine |
| Last Name | Kitamoto |
| First Name | Takuya |
| Address | 1-20-1 Handayama, Chuo-ku, Hamamatsu 431-3192, Japan |
| t.ktmt@hama-med.ac.jp | |
| Phone | +81-53-435-2987 |
| Submit Date | 2024-08-05 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-12-27 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO003572 |
| Collection Summary: | Primary cultured human preadipocytes were obtained from Zen-Bio, Inc., derived from the abdominal subcutaneous adipose tissue of a 38-year-old Caucasian woman. The cells were grown, differentiated, and collected as mature adipocytes on day 14. All experiments were performed in three independent replicates. |
| Sample Type: | White adipose |
