Summary of Study ST001961

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001248. The data can be accessed directly via it's Project DOI: 10.21228/M8D41C This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001961
Study TitleMetabolomics of brown adipose tissue in murine heart failure model
Study Typeuntargeted CE-TOF/MS metabolomic profiling
Study SummaryBrown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the changes of metabolites, we conducted the CE-TOF/MS analysis using BAT from TAC (thoracic aortic constriction) or sham-operated mice. In BAT from TAC-operated mice, we found increase of choline and glycerophosphorylcholine and a decrease of phosphorylcholine, suggesting that BAT dysfunction induces the disorientation of choline metabolism.
Juntendo University
DepartmentDepartment of Cardiovascular Biology and Medicine
Last NameYoshida
First NameYohko
Address2-1-1, Hongo, Bunkyo-ku, Tokyo, Tokyo, 1138421, Japan
Submit Date2021-10-13
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailMS(Dir. Inf.)
Release Date2022-11-01
Release Version1
Yohko Yoshida Yohko Yoshida application/zip

Select appropriate tab below to view additional metadata details:

Combined analysis:

Analysis ID AN003196 AN003197
Analysis type MS MS
Chromatography type None (Direct infusion) None (Direct infusion)
Chromatography system none none
Column none none
MS instrument type Single quadrupole Single quadrupole
MS instrument name Agilent 6224 TOF Agilent 6224 TOF
Units nmol/g nmol/g


Chromatography ID:CH002364
Instrument Name:none
Column Name:none
Chromatography Type:None (Direct infusion)