Summary of Study ST001328

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000906. The data can be accessed directly via it's Project DOI: 10.21228/M8KD7Z This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001328
Study TitleMultiplatform, non-targeted analysis of lung extracts of uninfected and Mtb-infected C57BL/6 mice at 4 and 9 weeks p.i.
Study SummaryThe goal of this multiplatform, non-targeted metabolomics study was to explore the metabolic alterations occurring during the natural progression of pulmonary tuberculosis in a murine model of disease (C57BL/6 genotype). For this purpose, we used gas chromatography, capillary electrophoresis, and reversed-phase liquid chromatography coupled to high-resolution mass analyzers (GC-EI-QTOF/MS, CE-ESI(+)-QTOF/MS, LC-ESI(+)-QTOF/MS and LC-ESI(-)-QTOF/MS to analyze lung extracts of age and sex-matched uninfected mice (UW, n=4), Mycobacterium tuberculosis-infected mice at 4 weeks post-infection (4W, n=4) and Mycobacterium tuberculosis-infected mice at 9 weeks post-infection. All data were acquired in MS1 mode, following a canonical non-targeted workflow.
Universidad CEU San Pablo
DepartmentDepartamento de Quimica y Bioquimica
LaboratoryCentro de Metabolomica y Bioanalisis (CEMBIO)
Last NameFernandez Garcia
First NameMiguel
AddressFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
Submit Date2020-03-12
Num Groups3
Total Subjects13
Num Males6
Num Females7
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailGC-MS/LC-MS
Release Date2021-03-15
Release Version1
Miguel Fernandez Garcia Miguel Fernandez Garcia application/zip

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Combined analysis:

Analysis ID AN002211 AN002212 AN002213 AN002214
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase GC CE
Chromatography system Agilent 1200 Agilent 1200 Agilent 7890B Agilent 7100 CE
Column Agilent Poroshell 120 EC-C8 (150 x 2.1mm,2.7um) Agilent Poroshell 120 EC-C8 (150 x 2.1mm,2.7um) Agilent DB5-MS (30m x 0.25mm, 0.25um) Agilent bare-fused silica capillary (96 cm x 50 um i.d.)
MS instrument type QTOF QTOF QTOF TOF
MS instrument name Agilent 6520 QTOF Agilent 6520 QTOF Agilent 7200 Agilent 6224 TOF
Units Abundance Abundance Abundance Abundance