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MB Sample ID: SA216497
Local Sample ID: | FIT01-098-pos |
Subject ID: | SU002337 |
Subject Type: | Human |
Subject Species: | Homo sapiens |
Taxonomy ID: | 9606 |
Age Or Age Range: | 6-17 years |
Weight Or Weight Range: | Non-exacerbation-prone IQR: 30-68 kg; Exacerbation-prone IQR: 42-63 kg |
Height Or Height Range: | Non-exacerbation-prone IQR: 131-165 cm; Exacerbation-prone IQR: 140-163 cm |
Gender: | Male and female |
Human Race: | 18 white, 189 Black, 7 more than one race, 1 Asian |
Human Ethnicity: | 2 Hispanic, 113 Not Hispanic |
Human Medications: | 92 on high-dose inhaled corticosteroids; 94 on long-acting beta adrenergic receptor agonists; 111 on Montelukast |
Human Smoking Status: | 24 exposed to tobacco smoke |
Human Inclusion Criteria: | 1) current or historical evidence of >=12% reversibility in forced expiratory volume in one second (FEV1) relative to baseline after bronchodilator administration; 2) airway hyperresponsiveness to methacholine, with a provocative concentration of methacholine causing a 20% drop in FEV1 |
Human Exclusion Criteria: | 1) premature birth before 35 weeks of gestation; 2) other chronic airway disorders that could mimic asthma. |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN003677 | AN003678 |
---|---|---|
Analysis type | MS | MS |
Chromatography type | HILIC | HILIC |
Chromatography system | Vanquish Horizon Binary ultrahigh performance liquid chromatography system | Vanquish Horizon Binary ultrahigh performance liquid chromatography system |
Column | SeQuant ZIC-HILIC | SeQuant ZIC-HILIC |
MS Type | ESI | ESI |
MS instrument type | Orbitrap | Orbitrap |
MS instrument name | Thermo Q Exactive HF hybrid Orbitrap | Thermo Q Exactive HF hybrid Orbitrap |
Ion Mode | POSITIVE | NEGATIVE |
Units | peak area | peak area |
MS:
MS ID: | MS003428 |
Analysis ID: | AN003677 |
Instrument Name: | Thermo Q Exactive HF hybrid Orbitrap |
Instrument Type: | Orbitrap |
MS Type: | ESI |
MS Comments: | Data were processed using Compound Discoverer 3.2 (Thermo). Minimum peak intensity was 5E5 for positive mode. Retention times were aligned across runs, quality control (QC) pooled sample areas were normalized per metabolite using a cubic spline method, requiring <50% relative standard deviation after correction for compound retention. Missing values were gap-filled based on real peak detection and metabolites with max sample area <5-fold that of the blank were censored. |
Ion Mode: | POSITIVE |
Capillary Temperature: | 275 |
Ion Spray Voltage: | +3.5 kV |
Automatic Gain Control: | 1E6 |
MS ID: | MS003429 |
Analysis ID: | AN003678 |
Instrument Name: | Thermo Q Exactive HF hybrid Orbitrap |
Instrument Type: | Orbitrap |
MS Type: | ESI |
MS Comments: | Data were processed using Compound Discoverer 3.2 (Thermo). Minimum peak intensity was 2E5 for negative mode. Retention times were aligned across runs, quality control (QC) pooled sample areas were normalized per metabolite using a cubic spline method, requiring <50% relative standard deviation after correction for compound retention. Missing values were gap-filled based on real peak detection and metabolites with max sample area <5-fold that of the blank were censored. |
Ion Mode: | NEGATIVE |
Capillary Temperature: | 275 |
Ion Spray Voltage: | -2.75 kV |
Automatic Gain Control: | 1E6 |