Summary of project PR002243
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002243. The data can be accessed directly via it's Project DOI: 10.21228/M8PR8Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002243 |
| Project DOI: | doi: 10.21228/M8PR8Q |
| Project Title: | Individual glycemic responses to carbohydrates vary and reflect underlying metabolic physiology |
| Project Summary: | Elevated postprandial glycemic responses (PPGRs) are associated with type 2 diabetes and cardiovascular disease. PPGRs to the same foods have been shown to vary between individuals, but the systematic characterization of the underlying physiologic and molecular basis is lacking. We measured PPGRs using continuous glucose monitoring (CGM) in 55 well-phenotyped participants challenged with seven different carbohydrates administered in replicate under standardized conditions. We also measured the effects of preloading a rice meal with fiber, protein, or fat (“mitigators”). To examine the physiologic and molecular basis for inter-individual PPGR differences, we performed gold-standard metabolic tests and multi-omics profiling. We discovered: 1. Postprandial glycemic responses (PPGRs) to different standardized carbohydrate meals vary between individuals. 2. Individuals’ PPGRs are associated with their metabolic phenotypes, including insulin resistance. 3. Individual’s PPGRs can be reduced in magnitude and delayed by premeal mitigators which is associated with their metabolic phenotypes. 4. Individuals can be stratified by their PPGRs to different carbohydrate meals, and PPGR subtypes have distinct metabolic profiles and multi-omics patterns. 5. Individuals’ metabolic phenotype can be inferred from both food-specific PPGRs and baseline omics. |
| Institute: | Stanford University |
| Department: | Genetics |
| Laboratory: | Michael P. Snyder |
| Last Name: | Snyder |
| First Name: | Michael |
| Address: | 300 Pasteur Drive, M-344A Stanford, California 94305 |
| Email: | mpsnyder@stanford.edu |
| Phone: | (650) 723-4668 |
| Funding Source: | NIH |
Summary of all studies in project PR002243
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003630 | Individual glycemic responses to carbohydrates vary and reflect underlying metabolic physiology (Lipidomics) | Homo sapiens | Stanford University | MS | 2025-01-12 | 1 | 113 | Uploaded data (13.8M)* |
| ST003636 | Individual glycemic responses to carbohydrates vary and reflect underlying metabolic physiology (metabolomics) | Homo sapiens | Stanford University | MS | 2025-01-14 | 1 | 113 | Uploaded data (92G)* |
