Summary of project PR002216
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002216. The data can be accessed directly via it's Project DOI: 10.21228/M85Z4M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002216 |
| Project DOI: | doi: 10.21228/M85Z4M |
| Project Title: | Metabolomics of the liver after administration of adenovirus associated with metabolic liver zonation |
| Project Summary: | Metabolic zonation in the liver is broadly defined as spatiotemporal variability in the intra-hepatic distribution of nutrients. R-spondin3 (Rspo3) regulates metabolic features around hepatic central veins. Herein, we demonstrate that altered hepatic metabolic zonation due to Rspo3 contributes to maintaining systemic glucose metabolism and body composition via inter-organ communication mechanism. Hepatic Rspo3 induction in obesity improves obesity-associated features by restoring insulin sensitivity, reversing adipose tissue enlargement and reversing overstimulated adaptive thermogenesis. These remote effects partly consist of neuronal communication via the afferent vagus from the liver. In contrast, hepatic Rspo3 suppression exacerbates diabetes due to insulin resistance and develops fatty liver. |
| Institute: | Teikyo University |
| Last Name: | Uno |
| First Name: | Kenji |
| Address: | 2-11-1 Kaga, Itabashi-ku, Tokyo |
| Email: | unok@med.teikyo-u.ac.jp |
| Phone: | 81339641211 |
Summary of all studies in project PR002216
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003586 | Metabolomics of the murine liver | Mus musculus | Teikyo University | MS | 2024-12-06 | 1 | 8 | Not available |
