Summary of project PR001743

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001743. The data can be accessed directly via it's Project DOI: 10.21228/M8DH7F This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001743
Project DOI:doi: 10.21228/M8DH7F
Project Title:Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia
Project Summary:The genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such as tanshinones and carnosic acids, are specific to Salvia and exhibit taxonomic chemical diversity among lineages. To elucidate how ATD chemical diversity evolved, we carried out large-scale metabolic and phylogenetic analyses of 71 Salvia species, combined with enzyme function, ancestral sequence and chemical trait reconstruction, and comparative genomics experiments. This integrated approach showed that the lineage-wide ATD diversities in Salvia were induced by differences in the oxidation of the terpenoid skeleton at C-20, which was caused by the functional divergence of the cytochrome P450 subfamily CYP76AK. These findings present a unique pattern of chemical diversity in plants that was shaped by the loss of enzyme activity and associated catalytic pathways.
Institute:Shanghai University of Traditional Chinese Medicine
Last Name:Chen
First Name:Wansheng
Address:NO. 1200 Cailun Road

Summary of all studies in project PR001743

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002795 Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia Salvia Shanghai University of Traditional Chinese Medicine MS 2023-08-15 1 71 Uploaded data (180.7G)*