Summary of project PR001742

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001742. The data can be accessed directly via it's Project DOI: 10.21228/M8J71N This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001742
Project DOI:doi: 10.21228/M8J71N
Project Title:Metabolomics Study on Plasma and Lung Tissue of Rats Exposed to Whole Thorax Irradiation
Project Type:MS quantitative analysis
Project Summary:Although some progress has been made in the study of radiation injury, there are still no effective prevention and treatment methods for severe acute radiation syndrome or sickness (ARS). Accordingly, a thorough understanding of biological characteristics associated with high-dose radiation is essential for revealing the mechanisms underlying the varied biological processes following high dose radiation and the development of novel potent radioprotective agents. Therefore, in this paper, we investigated the metabolic characteristics of plasma and lung tissue of rats exposed to whole-thorax irradiation (WTI) by liquid chromatography-mass spectrometry (LC-MS). The correlation of metabolic characteristics between plasma and lung tissue of WTI rats was studied. Parallel metabolic pathway analysis of common differential metabolites suggests that the metabolic characteristics of plasma can reflect the metabolic changes of RILI. On this basis, the potential plasma biomarkers of RILI (acylcarnitine C9:1, acylcarnitine C5:0, taurocholic acid and tauro-α-Muricholic acid) were screened, and their dose-response patterns suggest that they have the potential for early diagnosis and evaluation of RILI.
Institute:Soochow University
Last Name:Wang
First Name:Chang
Address:Suzhou, No. 199, Renai Road, Suzhou Industrial Park

Summary of all studies in project PR001742

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002794 Metabolomics Study on Plasma and Lung Tissue of Rats Exposed to Whole Thorax Irradiation. Rattus norvegicus Soochow University MS 2023-08-10 1 535 Uploaded data (1.3G)*