Summary of project PR001507

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001507. The data can be accessed directly via it's Project DOI: 10.21228/M8WQ53 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001507
Project DOI:doi: 10.21228/M8WQ53
Project Title:Impact of Visceral Leishmaniasis on Local Organ Metabolism in Hamsters
Project Summary:Leishmania is an intracellular parasite with different species pathogenic to humans and causing the disease leishmaniasis. Leishmania donovani causes visceral leishmaniasis (VL) that manifests as hepatosplenomegaly, fever, pancytopenia and hypergammaglobulinemia. If left without treatment, VL can cause death, especially in immunocompromised people. Current treatments have often significant adverse effects, and resistance has been reported in some countries. Determining the metabolites perturbed during VL can lead us to find new treatments targeting disease pathogenesis. We therefore compared metabolic perturbation between L. donovani-infected and uninfected hamsters across organs (spleen, liver, and gut). Metabolites were extracted, analyzed by liquid chromatography-mass spectrometry, and processed with MZmine and molecular networking to annotate metabolites. We found few metabolites commonly impacted by infection across all three sites, including glycerophospholipids, ceramides, acylcarnitines, peptides, purines and amino acids. In accordance with VL symptoms and parasite tropism, we found a greater overlap of perturbed metabolites between spleen and liver compared to spleen and gut, or liver and gut. Targeting pathways related to these metabolite families would be the next focus that can lead us to find more effective treatments for VL.
Institute:University of Oklahoma
Last Name:McCall
First Name:Laura-Isobel
Address:101 Stephenson Pkwy, Norman, OK, 73019-5251, USA

Summary of all studies in project PR001507

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002347 Impact of Visceral Leishmaniasis on Local Organ Metabolism in Hamsters Mesocricetus auratus University of Oklahoma MS* 2022-11-28 1 146 Uploaded data (1.9G)*