Summary of project PR001505

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001505. The data can be accessed directly via it's Project DOI: 10.21228/M85717 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001505
Project DOI:doi: 10.21228/M85717
Project Title:Stress-Induced Mucosal Layer Disruption Drives Gut Dysbiosis and Depressive-like Behaviors
Project Summary:Depression is a common mental health condition with a large social and economic impact. While depression etiology is multifactorial, chronic stress is a well-accepted contributor to disease onset. In addition, depression is associated with altered gut microbial signatures that can be replicated in animal models. While targeted restoration of the microbiome has been shown to reduce depressive-like behaviors in mice, the complexity and diversity of the human microbiome has complicated therapeutic intervention in patients. To circumvent these limitations, there is a critical need for identifying pathways responsible for microbiome dysbiosis. Here, for the first time, we identify the changes in host physiology that induce microbiome dysbiosis. Specifically, we show that a component of mucosal layer, the transmembrane protein mucin 13, can regulate microbiome composition. Using a model of chronic stress to induce behavioral and microbial changes in mice, we show a significant reduction in mucin 13 expression across the intestines that occurs independently of the microbiome. Furthermore, deleting Muc13 leads to gut dysbiosis, and baseline behavioral changes normally observed after stress exposure. Together, these results validate the hypothesis that mucosal layer disruption is an initiating event in stress-induced dysbiosis and offer mucin 13 as a potential new therapeutic target for microbiome dysbiosis in stress-induced depression. For the first time, our data provide an upstream and conserved target for treating microbiome dysbiosis, a result with sweeping implications for diseases presenting with microbial alterations.
Institute:University of Virginia
Laboratory:Gaultier Lab
Last Name:Rivet-Noor
First Name:Courtney
Address:409 Lane Road, Charlottsville, Virginia, 22903, USA
Funding Source:NIH

Summary of all studies in project PR001505

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002345 Stress-Induced Mucosal Layer Disruption Drives Gut Dysbiosis and Depressive-like Behaviors Mus musculus University of Virginia MS 2022-11-28 1 37 Uploaded data (1.3G)*