Summary of project PR001447

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001447. The data can be accessed directly via it's Project DOI: 10.21228/M8PH7X This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001447
Project DOI:doi: 10.21228/M8PH7X
Project Title:Multi-omic analysis reveals bacteria may have a role in dental erosion
Project Type:Research Study
Project Summary:NMR was performed on 11 saliva samples; 5 from participants classified as having dental erosion and 6 from healthy control participants with no dental erosion to assess the differences in metabolome between the two groups. NMR analysis alone revealed no significant differences between the dental erosion and healthy controls. However, bacterial mRNA sequencing of the oral microbiome from the same saliva samples was performed and the bacterial gene expression profiles was correlated to metabolite concentrations in the groups. The dental erosion group had strong correlations between metabolites associated with protein degradation and amino acid fermentation (formate, butyrate, propionate, 5-aminopentanoate, acetate, glycine, phenylalanine, dimethyl sulfone) and increased activity of species including 4 Prevotella species, Actinomyces graevenitzii, Tannerella species, and 2 Selenomas species, to name a few. Whereas in the healthy control group, the only positive correlations between metabolite concentrations and bacterial activity was for urea and 5-aminopentanoate; urea was positively correlated with Aggregatibacter actinomycetecomytans, Lysinibacillus fusiformis, and Veillonella tobetsuensis, and 5-aminopentanoate was positively correlated with 3 different Leptotrichia species, Streptococcus parasanguinis, and 2 Prevotella species.
Institute:King's College London
Department:Centre for Host Microbiome Interactions
Last Name:Cleaver
First Name:Leanne
Address:Floor 17, Tower Wing, Guy's Hospital, King's College London, Great Maze Pond

Summary of all studies in project PR001447

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002265 Multi-omic analysis reveals bacteria may have a role in dental erosion Homo sapiens King's College London NMR 2022-09-05 1 34 Uploaded data (26.4M)*