Summary of project PR001445

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001445. The data can be accessed directly via it's Project DOI: 10.21228/M8Z119 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001445
Project DOI:doi: 10.21228/M8Z119
Project Title:Intermittent fasting induces rapid hepatocyte proliferation to maintain the hepatostat
Project Summary:Nutrient availability fluctuates in most natural populations, forcing organisms to undergo periods of fasting and re-feeding. It is unknown how dietary change influences liver homeostasis. Here, we show that a switch from ad libitum feeding to intermittent fasting (IF) promotes rapid hepatocyte proliferation. Mechanistically, IF- induced hepatocyte proliferation is driven by the combined action of intestinally produced, systemic endocrine FGF15 and localized WNT signaling. IF proliferation re-establishes a constant liver-to-body-mass ratio during periods of fasting and re-feeding, a process termed the hepatostat. This study provides the first example of dietary influence on adult hepatocyte proliferation, and challenges the widely held view that liver tissue is mostly quiescent unless chemically or mechanically injured.
Institute:Stanford University
Last Name:DeFelice
First Name:Brian
Address:1291 Welch Rd., Rm. G0821 (SIM1), Stanford CA, California, 94305, USA

Summary of all studies in project PR001445

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002263 Intermittent fasting induces rapid hepatocyte proliferation to maintain the hepatostat Mus musculus Stanford University MS 2022-08-31 1 23 Uploaded data (1.6G)*