Summary of project PR001366

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001366. The data can be accessed directly via it's Project DOI: 10.21228/M85115 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001366
Project DOI:doi: 10.21228/M85115
Project Title:Improvement of cognitive function by B. breve MCC1274 and elucidation of its mechanism of action
Project Summary:Although many studies have suggested that probiotics could modulate various brain functions via the gut-brain axis, little is known about the mechanism underlying this process. We previously reported the beneficial effects of a probiotic strain, Bifidobacterium breve MCC1274, on cognitive function in preclinical and clinical studies. Recently, we showed that administration of this strain reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS.
Institute:Morinaga milk industry CO., LTD.
Department:Next generation science institute
Laboratory:Frontier research section
Last Name:Ohno
First Name:Kazuya
Address:1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan

Summary of all studies in project PR001366

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002153 Data from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274 Mus musculus Morinaga milk industry CO., LTD. MS 2022-10-03 1 16 Uploaded data (249.7K)