Summary of project PR001248

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001248. The data can be accessed directly via it's Project DOI: 10.21228/M8D41C This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001248
Project DOI:doi: 10.21228/M8D41C
Project Title:Metabolomics of brown adipose tissue in murine heart failure model
Project Type:untargeted CE-TOF/MS metabolomic profiling
Project Summary:Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the changes of metabolites, we conducted the CE-TOF/MS analysis using BAT from TAC (thoracic aortic constriction) or sham-operated mice. In BAT from TAC-operated mice, we found increase of choline and glycerophosphorylcholine and a decrease of phosphorylcholine, suggesting that BAT dysfunction induces the disorientation of choline metabolism.
Institute:Juntendo University
Department:Department of Cardiovascular Biology and Medicine
Last Name:Yoshida
First Name:Yohko
Address:2-1-1, Hongo, Bunkyo-ku, Tokyo, Tokyo, 1138421, Japan

Summary of all studies in project PR001248

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001961 Metabolomics of brown adipose tissue in murine heart failure model Mus musculus Juntendo University MS 2022-11-01 1 11 Uploaded data (12.6G)*