Summary of project PR001247

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001247. The data can be accessed directly via it's Project DOI: 10.21228/M8HT3Z This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001247
Project DOI:doi: 10.21228/M8HT3Z
Project Title:Lipidomics of brown adipocytes treated with d9-choline
Project Type:targeted LC-QTOF/MS lipidomic profiling
Project Summary:Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the detail effect of choline accumulation on brown adipocytes, we conducted the LC-QTOF/MS analysis using cultured brown adipocytes treated with d9-choline. In brown adipocytes treated with d9-choline, we found increase of phosphatidylcholine and lysophosphatidylcholine, suggesting that choline was metabolized in healthy brown adipocytes.
Institute:Juntendo University
Department:Department of Cardiovascular Biology and Medicine
Last Name:Yoshida
First Name:Yohko
Address:2-1-1, Hongo, Bunkyo-ku, Tokyo, Tokyo, 1138421, Japan

Summary of all studies in project PR001247

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001960 Lipidomics of brown adipocytes treated with d9-choline Mus musculus Juntendo University MS 2022-11-01 1 16 Uploaded data (9G)*