Summary of project PR000906

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000906. The data can be accessed directly via it's Project DOI: 10.21228/M8KD7Z This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000906
Project DOI:doi: 10.21228/M8KD7Z
Project Title:Pulmonary Tuberculosis Mice Project
Project Type:Natural disease progression assessment
Project Summary:The goal of this multiplatform, non-targeted metabolomics study was to explore the metabolic alterations occurring during the natural progression of pulmonary tuberculosis in a murine model of disease (C57BL/6 genotype). For this purpose, we used gas chromatography, capillary electrophoresis, and reversed-phase liquid chromatography coupled to high-resolution mass analyzers (GC-EI-QTOF/MS, CE-ESI(+)-QTOF/MS, LC-ESI(+)-QTOF/MS and LC-ESI(-)-QTOF/MS to analyze lung extracts of age and sex-matched uninfected mice (UW, n=4), Mycobacterium tuberculosis-infected mice at 4 weeks post-infection (4W, n=4) and Mycobacterium tuberculosis-infected mice at 9 weeks post-infection. All data were acquired in MS1 mode, following a canonical non-targeted workflow. The potential benefit for the general research community arising from the combination of these analyses is to generate mass spectrometry data which has not been previously described for this model of the disease. This data may serve as a foundation for the validation of observations, data modeling, and biochemical interpretation of MS-based metabolic changes found in the comparisons between the different sample groups
Institute:Universidad CEU San Pablo
Department:Departamento de Quimica y Bioquimica
Laboratory:Centro de Metabolomica y Bioanalisis (CEMBIO)
Last Name:Fernandez Garcia
First Name:Miguel
Address:Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain

Summary of all studies in project PR000906

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001328 Multiplatform, non-targeted analysis of lung extracts of uninfected and Mtb-infected C57BL/6 mice at 4 and 9 weeks p.i. Mus musculus Universidad CEU San Pablo MS* 2021-03-15 1 52 Uploaded data (12G)*