Summary of project PR000666

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000666. The data can be accessed directly via it's Project DOI: 10.21228/M8KQ3J This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000666
Project DOI:doi: 10.21228/M8KQ3J
Project Title:GC6-74 matabolomic of tuberculosis.
Project Type:Metabolomic analysis of TB vs heathy including time to TB.
Project Summary:Within the GC6-74 cohorts, 4,462 HIV-negative healthy household contacts of 1,098 index TB cases were recruited from 2006 to 2012 at four African sites included in this study i.e. SUN (Stellenbosch University, South Africa), MRC (Medical Research Council Unit, The Gambia), AHRI (Armauer Hansen Research Institute, Ethiopia) and MAK (Makerere University, Uganda). The study had an exclusion period of 3 months, such that participants, who were diagnosed with active TB within 3 months of enrolment, were excluded from analysis to prevent inclusion of participants who had incipient or asymptomatic clinical TB disease at enrolment. Additional exclusion criteria were positive HIV rapid test, current or previous anti-retroviral treatment, history of TB, pregnancy, participation in drug and/or vaccine clinical trials and chronic disease diagnosis or immunosuppressive therapy within the past 6 months, and living in the study area for less than 3 months. A total of 97 individuals who developed active TB within the two year follow-up period were included in this study and matched at a ratio of 1:4 with participants who remained healthy during the 2-year follow-up period (controls); matching, by site, age class, sex, and wherever possible year of recruitment. Initial samples collected upon enrolment were termed baseline (BL) samples. Further samples were taken 6 and 18 months post-exposure, provided that the participant had remained TB free at the time of sample collection. Metabolic profiling was carried out for each study site, using either serum or plasma samples. For a small number of samples, an insufficient amount of plasma was available, so the sample was diluted using RPMI buffer.
Institute:Max Planck Institute for Infection Biology
Last Name:Kaufmann
First Name:Stefan
Address:Charit├ęplatz 1,10117 Berlin, Berlin, Deutschland
Phone:+49 30 28460-500
Funding Source:Bill & Melinda Gates Foundation Grand Challenges in Global Health Program (BMGF GC6-74,#37772 and GC6-2013, OPP1055806)

Summary of all studies in project PR000666

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000974 GC6-74 matabolomic of TB (Part 1: Plasma) Homo sapiens Max Planck Institute for Infection Biology MS* 2018-11-05 1 366 Uploaded data (848K)
ST000975 GC6-74 metabolomics of TB vs healthy (Part 2: Serum) Homo sapiens Max Planck Institute for Infection Biology MS* 2018-11-05 1 340 Uploaded data (793.5K)
ST000976 GC6-74 matabolomic of TB (Part 3: Plasma_RPMI) Homo sapiens Max Planck Institute for Infection Biology MS* 2018-11-05 1 45 Uploaded data (77.7K)