Summary of project PR000348

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000348. The data can be accessed directly via it's Project DOI: 10.21228/M82K58 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000348
Project DOI:doi: 10.21228/M82K58
Project Title:Metabolic features of chronic fatigue
Project Type:Human plasma
Project Summary:More than 2 million people in the United States have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain insights into the biology of CFS. We studied a total of 84 subjects using these methods. Forty-five subjects (n = 22 men and 23 women) met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria. We targeted 612 metabolites in plasma from 63 biochemical pathways by hydrophilic interaction liquid chromatography, electrospray ionization, and tandem mass spectrometry in a single-injection method. Our data show that despite the heterogeneity of factors leading to CFS, the cellular metabolic response in patients was homogeneous, statistically robust, and chemically similar to the evolutionarily conserved persistence response to environmental stress known as dauer.
Institute:University of California, San Diego
Department:The Mitochondrial and Metabolic Disease Center
Last Name:Naviaux
First Name:Robert
Address:214 Dikinson Street, CTF-C102, San Diego, CA, 92103
Phone:(619) 993-2904
Funding Source:UCSD Christini Fund,The Wright Family Foundation,The Lennox Foundation, The It Takes Guts Foundation, The UCSD Mitochondrial Disease Research Fund
Publications:PNAS publication

Summary of all studies in project PR000348

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000450 Metabolic features of chronic fatigue syndrome Homo sapiens University of California, San Diego MS 2016-12-22 1 84 Uploaded data (658.6K)